ARFGEF1

GENE INFORMATION

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Gene name

ARFGEF1 (HGNC Symbol)

Synonyms

ARFGEP1, BIG1, DKFZP434L057, p200

Description

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) (HGNC Symbol)

Entrez gene summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]

Chromosome

8

Cytoband

q13.2

Chromosome location (bp)

67173512 - 67343677

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000066777 (version 78.38)

Entrez gene

10565

UniProt

Q9Y6D6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6D6

Antibodypedia

ARFGEF1 antibodies
 

PROTEIN VIEW

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ARFGEF1-001
 
ARFGEF1-002
 
ARFGEF1-003
 
ARFGEF1-006
 
ARFGEF1-007
 
ARFGEF1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARFGEF1-001 ENSP00000262215
ENST00000262215
Q9Y6D6
Show all »
Show » Show » 1849 208.8 No 0
ARFGEF1-002 ENSP00000429002
ENST00000519436
E5RJN9
Show all »
Show » 118 13.1 No 0
ARFGEF1-003 ENSP00000428429
ENST00000520381
E5RIF2
Show all »
Show » Show » 1254 142.5 No 0
ARFGEF1-006 ENSP00000429560
ENST00000518789
E5RHZ1
Show all »
Show » 155 18.2 No 0
ARFGEF1-007 ENSP00000430891
ENST00000518230
E5RHL7
Show all »
Show » Show » 702 80.5 No 0
ARFGEF1-011 ENSP00000429138
ENST00000517631
E5RJB2
Show all »
Show » 122 14.4 No 0