NEDD4

CANCER ATLAS

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Gene description

Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY

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HPA039883
 
CAB001991
 
CAB072833
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Most malignant cells showed weak to moderate cytoplasmic staining. Cases of malignant gliomas, one cervical squamous cell carcinoma and basal cell carcinoma exhibited strong positivity. Malignant carcinoids, colorectal and gastric cancers were generally negative.
 

Level of antibody staining/expression





High
Medium
Low
Not detected