PGR - Gene info - The Human Protein Atlas

Gene name

PGR (HGNC Symbol)

Synonyms

NR3C3, PR

Description

Progesterone receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]

Chromosome

Cytoband

q22.1

Chromosome location (bp)

101029624 - 101130524

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000082175 (version 78.38)

Entrez gene

5241

UniProt

P06401 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PGR-001

ENSP00000325120
ENST00000325455

P06401
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P06401 [Direct mapping]
Progesterone receptor
Q6TZ07 [Target identity:8%; Query identity:100%]
Progesterone receptor B isoform {ECO:0000313|EMBL:AAQ96834.1}

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Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001542 [ovulation from ovarian follicle]
GO:0002070 [epithelial cell maturation]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005102 [receptor binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0030879 [mammary gland development]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0060748 [tertiary branching involved in mammary gland duct morphogenesis]

933

PGR-002

ENSP00000436561
ENST00000534013

P06401
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P06401 [Direct mapping]
Progesterone receptor

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005102 [receptor binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

339

38.8

PGR-006

ENSP00000263463
ENST00000263463

P06401
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P06401 [Direct mapping]
Progesterone receptor
Q6TZ07 [Target identity:9%; Query identity:100%]
Progesterone receptor B isoform {ECO:0000313|EMBL:AAQ96834.1}

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Nuclear receptors
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005102 [receptor binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

831

87.7

PGR-201

ENSP00000481227
ENST00000617858

Q6TZ07
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Q6TZ07 [Target identity:11%; Query identity:100%]
Progesterone receptor B isoform {ECO:0000313|EMBL:AAQ96834.1}

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Nuclear receptors
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]

690

71.2

PGR-202

ENSP00000482698
ENST00000619228

Q8NG44
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Q8NG44 [Target identity:100%; Query identity:100%]
Delta 3+6/2 progesterone receptor {ECO:0000313|EMBL:BAC11011.1}; Progesterone receptor {ECO:0000313|Ensembl:ENSP00000432914}; Progesterone receptor, isoform CRA_e {ECO:0000313|EMBL:EAW67001.1}
Q6TZ07 [Target identity:10%; Query identity:100%]
Progesterone receptor B isoform {ECO:0000313|EMBL:AAQ96834.1}

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]

764

79.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.