APEX1 - Gene info - The Human Protein Atlas

APEX1

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	APEX1 (HGNC Symbol)
Synonyms	APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1
Description	APEX nuclease (multifunctional DNA repair enzyme) 1 (HGNC Symbol)
Entrez gene summary	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20455191 - 20457772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100823 (version 78.38)
Entrez gene	328
UniProt	P27695 (UniProt - Evidence at protein level)
neXtProt	NX_P27695
Antibodypedia	APEX1 antibodies

PROTEIN VIEW

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APEX1-001		APEX1-002		APEX1-003		APEX1-006		APEX1-008		APEX1-009		APEX1-013		APEX1-014		APEX1-016		APEX1-017		APEX1-018		APEX1-019		APEX1-021

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
APEX1-001	ENSP00000216714 ENST00000216714	P27695 Show all » « Hide P27695 [Direct mapping] DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial Q5TZP7 [Target identity:100%; Query identity:100%] APEX nuclease (Multifunctional DNA repair enzyme) 1 {ECO:0000313\|EMBL:AAV38935.1}; APEX nuclease (Multifunctional DNA repair enzyme) 1, isoform CRA_a {ECO:0000313\|EMBL:EAW66463.1}; Full-length cDNA clone CS0DI036YP02 of Placenta of Homo sapiens (human) {ECO:0000313\|EMBL:CAD61917.1}; cDNA FLJ76713, highly similar to Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, mRNA {ECO:0000313\|EMBL:BAF83789.1} G3V3M6 [Target identity:82%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451327} G3V3C7 [Target identity:54%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451170} G3V5D9 [Target identity:33%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000737 [DNA catabolic process, endonucleolytic] GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0004520 [endodeoxyribonuclease activity] GO:0004521 [endoribonuclease activity] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0004528 [phosphodiesterase I activity] GO:0004844 [uracil DNA N-glycosylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005840 [ribosome] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006310 [DNA recombination] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007568 [aging] GO:0008081 [phosphoric diester hydrolase activity] GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0010243 [response to organonitrogen compound] GO:0014912 [negative regulation of smooth muscle cell migration] GO:0016491 [oxidoreductase activity] GO:0016607 [nuclear speck] GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base] GO:0031490 [chromatin DNA binding] GO:0032403 [protein complex binding] GO:0042493 [response to drug] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0045454 [cell redox homeostasis] GO:0045739 [positive regulation of DNA repair] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051059 [NF-kappaB binding] GO:0055114 [oxidation-reduction process] GO:0070301 [cellular response to hydrogen peroxide] GO:0071320 [cellular response to cAMP] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071417 [cellular response to organonitrogen compound] GO:0080111 [DNA demethylation] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]	318	35.6	No	0
APEX1-002	ENSP00000451979 ENST00000555414	P27695 Show all » « Hide P27695 [Direct mapping] DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial Q5TZP7 [Target identity:100%; Query identity:100%] APEX nuclease (Multifunctional DNA repair enzyme) 1 {ECO:0000313\|EMBL:AAV38935.1}; APEX nuclease (Multifunctional DNA repair enzyme) 1, isoform CRA_a {ECO:0000313\|EMBL:EAW66463.1}; Full-length cDNA clone CS0DI036YP02 of Placenta of Homo sapiens (human) {ECO:0000313\|EMBL:CAD61917.1}; cDNA FLJ76713, highly similar to Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, mRNA {ECO:0000313\|EMBL:BAF83789.1} G3V3M6 [Target identity:82%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451327} G3V3C7 [Target identity:54%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451170} G3V5D9 [Target identity:33%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000737 [DNA catabolic process, endonucleolytic] GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0004520 [endodeoxyribonuclease activity] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0004528 [phosphodiesterase I activity] GO:0004844 [uracil DNA N-glycosylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005840 [ribosome] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006310 [DNA recombination] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008081 [phosphoric diester hydrolase activity] GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0016491 [oxidoreductase activity] GO:0016607 [nuclear speck] GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base] GO:0031490 [chromatin DNA binding] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0045739 [positive regulation of DNA repair] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0055114 [oxidation-reduction process] GO:0080111 [DNA demethylation] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]	318	35.6	No	0
APEX1-003	ENSP00000416414 ENST00000438886		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004518 [nuclease activity] GO:0006281 [DNA repair]	150	16.7	No	0
APEX1-006	ENSP00000452212 ENST00000557054		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		14	1.5	No	0
APEX1-008	ENSP00000381111 ENST00000398030	P27695 Show all » « Hide P27695 [Direct mapping] DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial Q5TZP7 [Target identity:100%; Query identity:100%] APEX nuclease (Multifunctional DNA repair enzyme) 1 {ECO:0000313\|EMBL:AAV38935.1}; APEX nuclease (Multifunctional DNA repair enzyme) 1, isoform CRA_a {ECO:0000313\|EMBL:EAW66463.1}; Full-length cDNA clone CS0DI036YP02 of Placenta of Homo sapiens (human) {ECO:0000313\|EMBL:CAD61917.1}; cDNA FLJ76713, highly similar to Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, mRNA {ECO:0000313\|EMBL:BAF83789.1} G3V3M6 [Target identity:82%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451327} G3V3C7 [Target identity:54%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451170} G3V5D9 [Target identity:33%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000737 [DNA catabolic process, endonucleolytic] GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0004520 [endodeoxyribonuclease activity] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0004528 [phosphodiesterase I activity] GO:0004844 [uracil DNA N-glycosylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005840 [ribosome] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006310 [DNA recombination] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008081 [phosphoric diester hydrolase activity] GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0016491 [oxidoreductase activity] GO:0016607 [nuclear speck] GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base] GO:0031490 [chromatin DNA binding] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0045739 [positive regulation of DNA repair] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0055114 [oxidation-reduction process] GO:0080111 [DNA demethylation] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]	318	35.6	No	0
APEX1-009	ENSP00000451327 ENST00000553681	G3V3M6 Show all » « Hide G3V3M6 [Target identity:100%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451327} G3V3C7 [Target identity:66%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451170} G3V5D9 [Target identity:40%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004518 [nuclease activity] GO:0005634 [nucleus] GO:0005813 [centrosome] GO:0006281 [DNA repair]	263	29.2	No	0
APEX1-013	ENSP00000452137 ENST00000557344	P27695 Show all » « Hide P27695 [Direct mapping] DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial G3V5D9 [Target identity:73%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000737 [DNA catabolic process, endonucleolytic] GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0004520 [endodeoxyribonuclease activity] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0004528 [phosphodiesterase I activity] GO:0004844 [uracil DNA N-glycosylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005840 [ribosome] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006310 [DNA recombination] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008081 [phosphoric diester hydrolase activity] GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0016491 [oxidoreductase activity] GO:0016607 [nuclear speck] GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base] GO:0031490 [chromatin DNA binding] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0045739 [positive regulation of DNA repair] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0055114 [oxidation-reduction process] GO:0080111 [DNA demethylation] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]	146	15.9	No	0
APEX1-014	ENSP00000452304 ENST00000557181	G3V5D9 Show all » « Hide G3V5D9 [Target identity:99%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0006281 [DNA repair]	108	11.8	No	0
APEX1-016	ENSP00000452460 ENST00000555839	G3V5Q1 Show all » « Hide G3V5Q1 [Target identity:100%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452460} G3V5D9 [Target identity:44%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0005634 [nucleus] GO:0005813 [centrosome] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis]	242	27.1	No	0
APEX1-017	ENSP00000451170 ENST00000556054	G3V3C7 Show all » « Hide G3V3C7 [Target identity:100%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451170} G3V5D9 [Target identity:61%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452304}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004518 [nuclease activity] GO:0006281 [DNA repair]	174	19.1	No	0
APEX1-018	ENSP00000451060 ENST00000557592	G3V359 Show all » « Hide G3V359 [Target identity:100%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451060} G3V5M0 [Target identity:94%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452418} G3V3Y6 [Target identity:23%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451491}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0005622 [intracellular] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis]	172	19.2	No	0
APEX1-019	ENSP00000451491 ENST00000553368	G3V3Y6 Show all » « Hide G3V3Y6 [Target identity:97%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451491}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		42	4.5	No	0
APEX1-021	ENSP00000452418 ENST00000557150	G3V5M0 Show all » « Hide G3V5M0 [Target identity:100%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000452418} G3V3Y6 [Target identity:25%; Query identity:100%] DNA-(apurinic or apyrimidinic site) lyase {ECO:0000313\|Ensembl:ENSP00000451491}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0005622 [intracellular] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis]	162	17.8	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.