GCK - Gene info - The Human Protein Atlas

Gene name

GCK (HGNC Symbol)

Synonyms

HK4, MODY2

Description

Glucokinase (hexokinase 4) (HGNC Symbol)

Entrez gene summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Chromosome

Cytoband

p13

Chromosome location (bp)

44144271 - 44198170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106633 (version 78.38)

Entrez gene

2645

UniProt

P35557 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCK-001

ENSP00000384247
ENST00000403799

P35557
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P35557 [Direct mapping]
Glucokinase
Q53Y25 [Target identity:100%; Query identity:100%]
Glucokinase (Hexokinase 4, maturity onset diabetes of the young 2) {ECO:0000313|EMBL:AAP35711.1}; Glucokinase (Hexokinase 4, maturity onset diabetes of the young 2), isoform CRA_b {ECO:0000313|EMBL:EAW61115.1}
M4PPE1 [Target identity:15%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08215.1}
M4PS83 [Target identity:10%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08223.1}

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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)

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GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006110 [regulation of glycolytic process]
GO:0008645 [hexose transport]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031018 [endocrine pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0050796 [regulation of insulin secretion]
GO:0051594 [detection of glucose]
GO:0055085 [transmembrane transport]

465

52.2

GCK-002

ENSP00000223366
ENST00000345378

P35557
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P35557 [Direct mapping]
Glucokinase
M4PPE1 [Target identity:15%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08215.1}
M4PS83 [Target identity:10%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08223.1}

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GO:0000287 [magnesium ion binding]
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005938 [cell cortex]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0006110 [regulation of glycolytic process]
GO:0006739 [NADP metabolic process]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008645 [hexose transport]
GO:0009749 [response to glucose]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019903 [protein phosphatase binding]
GO:0019932 [second-messenger-mediated signaling]
GO:0030141 [secretory granule]
GO:0031018 [endocrine pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0032869 [cellular response to insulin stimulus]
GO:0042149 [cellular response to glucose starvation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042593 [glucose homeostasis]
GO:0043266 [regulation of potassium ion transport]
GO:0043531 [ADP binding]
GO:0044281 [small molecule metabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045180 [basal cortex]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0050796 [regulation of insulin secretion]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0051594 [detection of glucose]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0070509 [calcium ion import]

466

52.1

GCK-003

ENSP00000379142
ENST00000395796

P35557
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464

GCK-004

ENSP00000402840
ENST00000437084

C9JQD1
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C9JQD1 [Target identity:100%; Query identity:100%]
Glucokinase {ECO:0000313|Ensembl:ENSP00000402840}
M4PPE1 [Target identity:15%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08215.1}
M4PS83 [Target identity:11%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08223.1}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

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GO:0004396 [hexokinase activity]
GO:0005524 [ATP binding]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0046835 [carbohydrate phosphorylation]

448

50.1

GCK-006

ENSP00000338009
ENST00000336642

H7BXV0
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H7BXV0 [Target identity:100%; Query identity:100%]
Glucokinase {ECO:0000313|Ensembl:ENSP00000338009}
M4PPE1 [Target identity:47%; Query identity:100%]
Glucokinase {ECO:0000313|EMBL:AGH08215.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

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GO:0005524 [ATP binding]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]

149

15.9

GCK-201

ENSP00000482149
ENST00000616242

P35557
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464

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.