SLC6A4

GENE INFORMATION

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Gene name

SLC6A4 (HGNC Symbol)

Synonyms

5-HTT, HTT, OCD1, SERT1

Description

Solute carrier family 6 (neurotransmitter transporter), member 4 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q11.2

Chromosome location (bp)

30194319 - 30236002

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108576 (version 78.38)

Entrez gene

6532

UniProt

P31645 (UniProt - Evidence at protein level)

neXtProt

NX_P31645

Antibodypedia

SLC6A4 antibodies
 

PROTEIN VIEW

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SLC6A4-001
 
SLC6A4-002
 
SLC6A4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC6A4-001 ENSP00000378298
ENST00000394821
J3KPR9
Show all »
Show » Show » 618 69 No >9
SLC6A4-002 ENSP00000385822
ENST00000401766
P31645
Show all »
Show » Show » 630 70.3 No >9
SLC6A4-201 ENSP00000261707
ENST00000261707
P31645
Show all »
Show » Show » 630 70.3 No >9