SLC11A2 - Gene info - The Human Protein Atlas

SLC11A2

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	SLC11A2 (HGNC Symbol)
Synonyms	DCT1, DMT1, NRAMP2
Description	Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	50979401 - 51028566
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110911 (version 78.38)
Entrez gene	4891
UniProt	P49281 (UniProt - Evidence at protein level)
neXtProt	NX_P49281
Antibodypedia	SLC11A2 antibodies

PROTEIN VIEW

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SLC11A2-001		SLC11A2-002		SLC11A2-003		SLC11A2-005		SLC11A2-006		SLC11A2-007		SLC11A2-008		SLC11A2-010		SLC11A2-011		SLC11A2-012		SLC11A2-014		SLC11A2-017		SLC11A2-020		SLC11A2-025		SLC11A2-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC11A2-001	ENSP00000449200 ENST00000547688	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:81%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:69%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:16%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:14%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	590	64.7	No	>9
SLC11A2-002	ENSP00000262052 ENST00000262052	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:85%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:73%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	561	61.5	No	>9
SLC11A2-003	ENSP00000446914 ENST00000546743	F8W1P7 Show all » « Hide F8W1P7 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:85%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8W1F2 [Target identity:31%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:20%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:18%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	482	52.8	No	>9
SLC11A2-005	ENSP00000444542 ENST00000541174	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:85%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:73%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	561	61.5	No	>9
SLC11A2-006	ENSP00000262051 ENST00000262051	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	568	62.3	No	>9
SLC11A2-007	ENSP00000446769 ENST00000547198	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	568	62.3	No	>9
SLC11A2-008	ENSP00000442810 ENST00000545993	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:86%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:73%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	557	61	No	>9
SLC11A2-010	ENSP00000447482 ENST00000547579	F8W1F2 Show all » « Hide F8W1F2 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:65%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:58%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	150	16.5	No	4
SLC11A2-011	ENSP00000446984 ENST00000550714	F8W1C0 Show all » « Hide F8W1C0 [Target identity:99%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446984} F8W154 [Target identity:66%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:58%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	148	16.1	No	4
SLC11A2-012	ENSP00000450389 ENST00000546488	F8VR36 Show all » « Hide F8VR36 [Target identity:99%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000450389}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	154	16.9	No	3
SLC11A2-014	ENSP00000447102 ENST00000547732	F8W154 Show all » « Hide F8W154 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:88%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	98	10.6	No	2
SLC11A2-017	ENSP00000447334 ENST00000549110	F8VZL6 Show all » « Hide F8VZL6 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	87	9.5	No	2
SLC11A2-020	ENSP00000449209 ENST00000548193	F8VWB0 Show all » « Hide F8VWB0 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	149	16.3	No	2
SLC11A2-025	ENSP00000448273 ENST00000548150		Show » « Hide Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)		3	0.4	No	0
SLC11A2-201	ENSP00000378364 ENST00000394904	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:81%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:69%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:16%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:14%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000041 [transition metal ion transport] GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005381 [iron ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005506 [iron ion binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006783 [heme biosynthetic process] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006826 [iron ion transport] GO:0006828 [manganese ion transport] GO:0006878 [cellular copper ion homeostasis] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007611 [learning or memory] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0010042 [response to manganese ion] GO:0010288 [response to lead ion] GO:0012505 [endomembrane system] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016151 [nickel cation binding] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030145 [manganese ion binding] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0046686 [response to cadmium ion] GO:0046870 [cadmium ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048813 [dendrite morphogenesis] GO:0048821 [erythrocyte development] GO:0050897 [cobalt ion binding] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071281 [cellular response to iron ion] GO:0071356 [cellular response to tumor necrosis factor] GO:0071421 [manganese ion transmembrane transport] GO:0071456 [cellular response to hypoxia] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] GO:1902861 [copper ion import into cell]	590	64.7	No	>9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.