ABCC5

GENE INFORMATION

? »

Gene name

ABCC5 (HGNC Symbol)

Synonyms

EST277145, MOAT-C, MRP5, SMRP

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q27.1

Chromosome location (bp)

183919934 - 184018015

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114770 (version 78.38)

Entrez gene

10057

UniProt

O15440 (UniProt - Evidence at protein level)

neXtProt

NX_O15440

Antibodypedia

ABCC5 antibodies
 

PROTEIN VIEW

? »
 
 
 
ABCC5-001
 
ABCC5-002
 
ABCC5-004
 
ABCC5-005
 
ABCC5-006
 
ABCC5-010
 
ABCC5-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC5-001 ENSP00000333926
ENST00000334444
O15440
Show all »
Show » Show » 1437 160.7 No >9
ABCC5-002 ENSP00000390911
ENST00000446941
E9PET4
Show all »
Show » 53 6.2 No 0
ABCC5-004 ENSP00000376358
ENST00000392579
O15440
Show all »
Show » Show » 225 25.3 No 1
ABCC5-005 ENSP00000371934
ENST00000382494
O15440
Show all »
Show » Show » 208 23.7 No 1
ABCC5-006 ENSP00000404809
ENST00000427120
A5PKY6
Show all »
Show » 231 26.2 No 1
ABCC5-010 ENSP00000399726
ENST00000437341
C9JZL5
Show all »
Show » 147 16.7 No 0
ABCC5-201 ENSP00000265586
ENST00000265586
O15440
Show all »
Show » Show » 1394 155.7 No >9