SDC1

GENE INFORMATION

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Gene name

SDC1 (HGNC Symbol)

Synonyms

CD138, SDC, SYND1, syndecan

Description

Syndecan 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p24.1

Chromosome location (bp)

20200797 - 20225433

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115884 (version 78.38)

Entrez gene

6382

UniProt

P18827 (UniProt - Evidence at protein level)

neXtProt

NX_P18827

Antibodypedia

SDC1 antibodies
 

PROTEIN VIEW

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SDC1-001
 
SDC1-002
 
SDC1-005
 
SDC1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SDC1-001 ENSP00000254351
ENST00000254351
P18827
Show all »
Show » Show » 310 32.5 Yes 1
SDC1-002 ENSP00000384613
ENST00000403076
E9PHH3
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Show » Show » 169 17.8 Yes 0
SDC1-005 ENSP00000400773
ENST00000429035
H7C1K4
Show all »
Show » Show » 215 22 No 0
SDC1-201 ENSP00000370542
ENST00000381150
P18827
Show all »
Show » Show » 310 32.5 Yes 1