RPS6

GENE INFORMATION

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Gene name

RPS6 (HGNC Symbol)

Synonyms

S6

Description

Ribosomal protein S6 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

p22.1

Chromosome location (bp)

19375715 - 19380254

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137154 (version 78.38)

Entrez gene

6194

UniProt

P62753 (UniProt - Evidence at protein level)

neXtProt

NX_P62753

Antibodypedia

RPS6 antibodies
 

PROTEIN VIEW

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RPS6-001
 
RPS6-002
 
RPS6-003
 
RPS6-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPS6-001 ENSP00000369757
ENST00000380394
P62753
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Show » Show » 249 28.7 No 0
RPS6-002 ENSP00000369745
ENST00000380384
A2A3R5
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Show » Show » 218 25 No 0
RPS6-003 ENSP00000369743
ENST00000315377
A2A3R5
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Show » Show » 218 25 No 0
RPS6-004 ENSP00000369741
ENST00000380381
A2A3R7
Show all »
Show » Show » 91 10.4 No 0