AGTR1 - Gene info - The Human Protein Atlas

AGTR1

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	AGTR1 (HGNC Symbol)
Synonyms	AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R
Description	Angiotensin II receptor, type 1 (HGNC Symbol)
Entrez gene summary	Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Chromosome	3
Cytoband	q24
Chromosome location (bp)	148697784 - 148743008
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144891 (version 78.38)
Entrez gene	185
UniProt	P30556 (UniProt - Evidence at protein level)
neXtProt	NX_P30556
Antibodypedia	AGTR1 antibodies

PROTEIN VIEW

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AGTR1-001		AGTR1-002		AGTR1-003		AGTR1-005		AGTR1-006		AGTR1-007		AGTR1-201		AGTR1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
AGTR1-001	ENSP00000273430 ENST00000349243	P30556 Show all » « Hide P30556 [Direct mapping] Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	359	41.1	No	7
AGTR1-002	ENSP00000419422 ENST00000497524	P30556 Show all » « Hide P30556 [Direct mapping] Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	359	41.1	No	7
AGTR1-003	ENSP00000385612 ENST00000404754	P30556 Show all » « Hide P30556 [Direct mapping] Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	359	41.1	No	7
AGTR1-005	ENSP00000419783 ENST00000475347	P30556 Show all » « Hide P30556 [Direct mapping] Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	359	41.1	No	7
AGTR1-006	ENSP00000418084 ENST00000474935	P30556 Show all » « Hide P30556 [Direct mapping] Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	359	41.1	No	7
AGTR1-007	ENSP00000418851 ENST00000461609	P30556 Show all » « Hide P30556 [Direct mapping] Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	359	41.1	No	7
AGTR1-201	ENSP00000385641 ENST00000402260	Q53YY0 Show all » « Hide Q53YY0 [Target identity:92%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	388	44.2	No	7
AGTR1-202	ENSP00000398832 ENST00000418473	D3DNG8 Show all » « Hide D3DNG8 [Target identity:100%; Query identity:100%] Angiotensin II receptor, type 1, isoform CRA_a {ECO:0000313\|EMBL:EAW78909.1} Q53YY0 [Target identity:91%; Query identity:100%] Angiotensin II receptor, type 1 {ECO:0000313\|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313\|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313\|EMBL:BAF84230.1} Q13063 [Target identity:10%; Query identity:100%] Type 1 angiotensin II receptor isoform {ECO:0000313\|EMBL:AAB35647.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	394	44.9	No	7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.