IGFBP3 - Gene info - The Human Protein Atlas

Gene name

IGFBP3 (HGNC Symbol)

Synonyms

BP-53, IBP3

Description

Insulin-like growth factor binding protein 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p12.3

Chromosome location (bp)

45912245 - 45921874

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146674 (version 78.38)

Entrez gene

3486

UniProt

P17936 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFBP3-001

ENSP00000275521
ENST00000275521

P17936
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P17936 [Direct mapping]
Insulin-like growth factor-binding protein 3
B4DN53 [Target identity:94%; Query identity:100%]
cDNA FLJ52568, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG60115.1}
B3KPF0 [Target identity:25%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001558 [regulation of cell growth]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009968 [negative regulation of signal transduction]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0031994 [insulin-like growth factor I binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0044267 [cellular protein metabolic process]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0046872 [metal ion binding]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0070062 [extracellular vesicular exosome]

291

31.7

Yes

IGFBP3-008

ENSP00000370476
ENST00000381086

B3KWK7
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B3KWK7 [Target identity:100%; Query identity:100%]
Insulin-like growth factor binding protein 3, isoform CRA_b {ECO:0000313|EMBL:EAW61026.1}; Insulin-like growth factor-binding protein 3 {ECO:0000313|Ensembl:ENSP00000370476}; cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG54169.1}
B3KPF0 [Target identity:38%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]

194

21.8

IGFBP3-014

ENSP00000389668
ENST00000448817

C9JMX4
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C9JMX4 [Target identity:100%; Query identity:100%]
Insulin-like growth factor-binding protein 3 {ECO:0000313|Ensembl:ENSP00000389668}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]

132

14.9

IGFBP3-018

ENSP00000390298
ENST00000428530

B3KPF0
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B3KPF0 [Target identity:52%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

143

16.4

IGFBP3-019

ENSP00000399116
ENST00000417621

B3KPF0
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B3KPF0 [Target identity:49%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

153

17.5

IGFBP3-020

ENSP00000370473
ENST00000381083

P17936
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P17936 [Direct mapping]
Insulin-like growth factor-binding protein 3
B3KPF0 [Target identity:25%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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GO:0001558 [regulation of cell growth]
GO:0001649 [osteoblast differentiation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009968 [negative regulation of signal transduction]
GO:0010906 [regulation of glucose metabolic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0031994 [insulin-like growth factor I binding]
GO:0040008 [regulation of growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0044342 [type B pancreatic cell proliferation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0046872 [metal ion binding]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0070062 [extracellular vesicular exosome]

297

32.2

Yes

IGFBP3-201

ENSP00000477772
ENST00000613132

A6XND0
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A6XND0 [Target identity:100%; Query identity:100%]
Insulin-like growth factor binding protein 3 {ECO:0000313|EMBL:ABI63364.1}
B3KPF0 [Target identity:27%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001558 [regulation of cell growth]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]

270

29.7

Yes

IGFBP3-202

ENSP00000480717
ENST00000615754

A6XND1
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A6XND1 [Target identity:100%; Query identity:100%]
Insulin-like growth factor binding protein 3 isoform b {ECO:0000313|EMBL:ABI63365.1}
B3KPF0 [Target identity:28%; Query identity:100%]
cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001558 [regulation of cell growth]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]

263

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.