AKAP6 - Gene info - The Human Protein Atlas

Gene name

AKAP6 (HGNC Symbol)

Synonyms

ADAP6, AKAP100, KIAA0311, mAKAP, PRKA6

Description

A kinase (PRKA) anchor protein 6 (HGNC Symbol)

Entrez gene summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q12

Chromosome location (bp)

32329273 - 32837681

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151320 (version 78.38)

Entrez gene

9472

UniProt

Q13023 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKAP6-001

ENSP00000280979
ENST00000280979

Q13023
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Q13023 [Direct mapping]
A-kinase anchor protein 6
D3DS91 [Target identity:89%; Query identity:100%]
A kinase (PRKA) anchor protein 6, isoform CRA_b {ECO:0000313|EMBL:EAW65933.1}
G3V3H2 [Target identity:15%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451239}
G3V3B5 [Target identity:4%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451146}
G3V569 [Target identity:2%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000452204}
G3V3H6 [Target identity:1%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451246}

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THUMBUP predicted membrane proteins
SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

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GO:0001508 [action potential]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005901 [caveola]
GO:0006605 [protein targeting]
GO:0008179 [adenylate cyclase binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0014704 [intercalated disc]
GO:0016529 [sarcoplasmic reticulum]
GO:0019933 [cAMP-mediated signaling]
GO:0030307 [positive regulation of cell growth]
GO:0030315 [T-tubule]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0032514 [positive regulation of protein phosphatase type 2B activity]
GO:0032947 [protein complex scaffold]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034704 [calcium channel complex]
GO:0043495 [protein anchor]
GO:0044325 [ion channel binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051018 [protein kinase A binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
GO:0060306 [regulation of membrane repolarization]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071320 [cellular response to cAMP]
GO:0071345 [cellular response to cytokine stimulus]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]

2319

256.7

AKAP6-002

ENSP00000450531
ENST00000557354

Q13023
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Q13023 [Direct mapping]
A-kinase anchor protein 6
G3V3H2 [Target identity:33%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451239}
G3V3B5 [Target identity:10%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451146}
G3V569 [Target identity:4%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000452204}
G3V3H6 [Target identity:2%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451246}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)

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1075

120.2

AKAP6-003

ENSP00000451239
ENST00000553547

G3V3H2
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G3V3H2 [Target identity:99%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451239}
G3V569 [Target identity:13%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000452204}
G3V3H6 [Target identity:7%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451246}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

357

38.5

AKAP6-004

ENSP00000451247
ENST00000557272

G3V3H7
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G3V3H7 [Target identity:100%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451247}
G3V3H2 [Target identity:28%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451239}
G3V3B5 [Target identity:8%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451146}
G3V569 [Target identity:3%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000452204}
G3V3H6 [Target identity:2%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451246}

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THUMBUP predicted membrane proteins
SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

1245

139.6

AKAP6-005

ENSP00000451146
ENST00000557102

G3V3B5
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G3V3B5 [Target identity:100%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451146}

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SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

108

12.3

AKAP6-008

ENSP00000451246
ENST00000554410

G3V3H6
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G3V3H6 [Target identity:100%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451246}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

AKAP6-009

ENSP00000452204
ENST00000556638

G3V569
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G3V569 [Target identity:100%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000452204}
G3V3H6 [Target identity:53%; Query identity:100%]
A-kinase anchor protein 6 {ECO:0000313|Ensembl:ENSP00000451246}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

5.2

AKAP6-015

ENSP00000452109
ENST00000554740

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

118

13.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.