ACE

GENE INFORMATION

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Gene name

ACE (HGNC Symbol)

Synonyms

ACE1, CD143, DCP1

Description

Angiotensin I converting enzyme (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Chromosome

17

Cytoband

q23.3

Chromosome location (bp)

63477061 - 63498380

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159640 (version 78.38)

Entrez gene

1636

UniProt

P12821 (UniProt - Evidence at protein level)

neXtProt

NX_P12821

Antibodypedia

ACE antibodies
 

PROTEIN VIEW

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ACE-001
 
ACE-007
 
ACE-009
 
ACE-011
 
ACE-017
 
ACE-020
 
ACE-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACE-001 ENSP00000290866
ENST00000290866
P12821
Show all »
Show » Show » 1306 149.7 Yes 1
ACE-007 ENSP00000290863
ENST00000290863
P12821
Show all »
Show » Show » 732 83.3 Yes 1
ACE-009 ENSP00000392247
ENST00000413513
P12821
Show all »
Show » Show » 691 78.7 Yes 1
ACE-011 ENSP00000462280
ENST00000582627
J3KS28
Show all »
Show » Show » 314 35.5 No 0
ACE-017 ENSP00000462909
ENST00000582761
J3KTB8
Show all »
Show » Show » 282 33 No 0
ACE-020 ENSP00000464428
ENST00000579409
Show » Show » 138 15.4 No 0
ACE-201 ENSP00000397593
ENST00000428043
Q3KRI5
Show all »
Show » Show » 1242 142.4 Yes 0