ZYX

GENE INFORMATION

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Gene name

ZYX

Synonyms

Description

Zyxin (HGNC Symbol)

Entrez gene summary

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q34

Chromosome location (bp)

143381080 - 143391111

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159840 (version 78.38)

Entrez gene

7791

UniProt

Q15942 (UniProt - Evidence at protein level)

neXtProt

NX_Q15942

Antibodypedia

ZYX antibodies
 

PROTEIN VIEW

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ZYX-001
 
ZYX-003
 
ZYX-005
 
ZYX-006
 
ZYX-007
 
ZYX-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ZYX-001 ENSP00000324422
ENST00000322764
Q15942
Show all »
Show » Show » 572 61.3 No 0
ZYX-003 ENSP00000403714
ENST00000446634
C9JJK5
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Show » Show » 171 19.1 No 0
ZYX-005 ENSP00000413467
ENST00000449630
H7C3R3
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Show » 178 18.6 No 0
ZYX-006 ENSP00000346417
ENST00000354434
H0Y2Y8
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Show » Show » 540 57.6 No 0
ZYX-007 ENSP00000376642
ENST00000392910
B4DQX7
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Show » Show » 415 45.1 No 0
ZYX-010 ENSP00000400537
ENST00000457235
C9IZ41
Show all »
Show » 164 17.1 No 0