ASGR2

GENE INFORMATION

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Gene name

ASGR2 (HGNC Symbol)

Synonyms

CLEC4H2

Description

Asialoglycoprotein receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7101322 - 7115700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161944 (version 78.38)

Entrez gene

433

UniProt

P07307 (UniProt - Evidence at protein level)

neXtProt

NX_P07307

Antibodypedia

ASGR2 antibodies
 

PROTEIN VIEW

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ASGR2-001
 
ASGR2-002
 
ASGR2-003
 
ASGR2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASGR2-001 ENSP00000254850
ENST00000254850
P07307
Show all »
Show » Show » 287 32.6 No 0
ASGR2-002 ENSP00000347140
ENST00000355035
P07307
Show all »
Show » Show » 311 35.1 No 1
ASGR2-003 ENSP00000405844
ENST00000446679
P07307
Show all »
Show » Show » 292 33 No 0
ASGR2-007 ENSP00000458835
ENST00000574868
I3L1H2
Show all »
Show » 135 14.7 No 1