ANTXR1

GENE INFORMATION

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Gene name

ANTXR1 (HGNC Symbol)

Synonyms

ATR, FLJ10601, FLJ21776, TEM8

Description

Anthrax toxin receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

Chromosome

2

Cytoband

p13.3

Chromosome location (bp)

69013178 - 69249327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169604 (version 78.38)

Entrez gene

84168

UniProt

Q9H6X2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H6X2

Antibodypedia

ANTXR1 antibodies
 

PROTEIN VIEW

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ANTXR1-001
 
ANTXR1-002
 
ANTXR1-003
 
ANTXR1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANTXR1-001 ENSP00000301945
ENST00000303714
Q9H6X2
Show all »
Show » Show » 564 62.8 Yes 1
ANTXR1-002 ENSP00000386494
ENST00000409349
Q9H6X2
Show all »
Show » Show » 368 41.2 Yes 1
ANTXR1-003 ENSP00000387058
ENST00000409829
Q9H6X2
Show all »
Show » Show » 333 37.1 Yes 0
ANTXR1-005 ENSP00000430776
ENST00000482235
Show » Show » 179 19.7 No 0