ATR

GENE INFORMATION

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Gene name

ATR (HGNC Symbol)

Synonyms

FRP1, MEC1, SCKL, SCKL1

Description

ATR serine/threonine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q23

Chromosome location (bp)

142449235 - 142578826

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175054 (version 78.38)

Entrez gene

545

UniProt

Q13535 (UniProt - Evidence at protein level)

neXtProt

NX_Q13535

Antibodypedia

ATR antibodies
 

PROTEIN VIEW

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ATR-001
 
ATR-002
 
ATR-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATR-001 ENSP00000343741
ENST00000350721
Q13535
Show all »
Show » Show » 2644 301.4 No 1
ATR-002 ENSP00000424355
ENST00000513291
Show » Show » 457 52.2 No 0
ATR-005 ENSP00000425897
ENST00000515149
D6RIG7
Show all »
Show » 309 35.4 No 0