AURKB - Gene info - The Human Protein Atlas

Gene name

AURKB (HGNC Symbol)

Synonyms

Aik2, AIM-1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5

Description

Aurora kinase B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

Cytoband

p13.1

Chromosome location (bp)

8204733 - 8210600

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178999 (version 78.38)

Entrez gene

9212

UniProt

Q96GD4 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AURKB-001

ENSP00000463999
ENST00000585124

Q96GD4
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Q96GD4 [Direct mapping]
Aurora kinase B
J3KTD6 [Target identity:66%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462930}
J3QR41 [Target identity:50%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000464031}
J3KRJ2 [Target identity:20%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462027}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0016570 [histone modification]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031565 [cytokinesis checkpoint]
GO:0031577 [spindle checkpoint]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0045171 [intercellular bridge]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051256 [spindle midzone assembly involved in mitosis]
GO:0051983 [regulation of chromosome segregation]

344

39.3

AURKB-002

ENSP00000313950
ENST00000316199

Q96GD4
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Q96GD4 [Direct mapping]
Aurora kinase B
J3QLN8 [Target identity:66%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000463636}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0010369 [chromocenter]
GO:0016570 [histone modification]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031565 [cytokinesis checkpoint]
GO:0031577 [spindle checkpoint]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0045171 [intercellular bridge]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051256 [spindle midzone assembly involved in mitosis]
GO:0051983 [regulation of chromosome segregation]

345

39.5

AURKB-003

ENSP00000443869
ENST00000534871

Q96GD4
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Q96GD4 [Direct mapping]
Aurora kinase B
J3QR41 [Target identity:56%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000464031}
J3KRJ2 [Target identity:22%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462027}

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303

34.8

AURKB-005

ENSP00000462207
ENST00000578549

Q96GD4
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Q96GD4 [Direct mapping]
Aurora kinase B

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0016570 [histone modification]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031565 [cytokinesis checkpoint]
GO:0031577 [spindle checkpoint]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0045171 [intercellular bridge]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051256 [spindle midzone assembly involved in mitosis]
GO:0051983 [regulation of chromosome segregation]

312

35.3

AURKB-008

ENSP00000462930
ENST00000581511

J3KTD6
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J3KTD6 [Target identity:100%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462930}
J3QR41 [Target identity:75%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000464031}
J3KRJ2 [Target identity:30%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462027}

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0031577 [spindle checkpoint]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0045171 [intercellular bridge]

228

26.2

AURKB-009

ENSP00000462027
ENST00000583915

J3KRJ2
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J3KRJ2 [Target identity:98%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462027}

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0031577 [spindle checkpoint]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0043988 [histone H3-S28 phosphorylation]

7.8

AURKB-011

ENSP00000464031
ENST00000582368

J3QR41
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J3QR41 [Target identity:100%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000464031}
J3KRJ2 [Target identity:40%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000462027}

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0031577 [spindle checkpoint]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0043988 [histone H3-S28 phosphorylation]

172

AURKB-012

ENSP00000463636
ENST00000577833

J3QLN8
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J3QLN8 [Target identity:99%; Query identity:100%]
Aurora kinase B {ECO:0000313|Ensembl:ENSP00000463636}

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MEMSAT-SVM predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0031577 [spindle checkpoint]
GO:0032467 [positive regulation of cytokinesis]

231

26.8

AURKB-016

ENSP00000462858
ENST00000584972

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

242

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.