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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
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Gene name |
LPAR1 (HGNC Symbol) |
Synonyms |
edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1 |
Description |
Lysophosphatidic acid receptor 1 (HGNC Symbol) |
Entrez gene summary |
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008] |
Chromosome |
9 |
Cytoband |
q31.3 |
Chromosome location (bp) |
110873263 - 111038458 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000198121 (version 78.38) |
Entrez gene |
1902 |
UniProt |
Q92633 (UniProt - Evidence at protein level) |
neXtProt |
NX_Q92633 |
Antibodypedia |
LPAR1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| LPAR1-001 |
ENSP00000363553
ENST00000374431
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Q92633
Show all »
« Hide
Q92633 [Direct mapping]Lysophosphatidic acid receptor 1 Q5VZX0 [Target identity:100%; Query identity:100%]Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a {ECO:0000313|EMBL:EAW59068.1}; cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG51118.1}; cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA {ECO:0000313|EMBL:BAF82976.1} Q6GPG7 [Target identity:95%; Query identity:100%]LPAR1 protein {ECO:0000313|EMBL:AAH73167.1}; cDNA FLJ51746, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG61296.1} B1AP63 [Target identity:50%; Query identity:100%]Lysophosphatidic acid receptor 1 {ECO:0000313|Ensembl:ENSP00000401810}
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G-protein coupled receptors
GPCRs excl olfactory receptors
Lysolipids receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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364 |
41.1 |
No |
7 |
| LPAR1-002 |
ENSP00000363552
ENST00000374430
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Q92633
Show all »
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Q92633 [Direct mapping]Lysophosphatidic acid receptor 1 Q5VZX0 [Target identity:100%; Query identity:100%]Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a {ECO:0000313|EMBL:EAW59068.1}; cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG51118.1}; cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA {ECO:0000313|EMBL:BAF82976.1} Q6GPG7 [Target identity:95%; Query identity:100%]LPAR1 protein {ECO:0000313|EMBL:AAH73167.1}; cDNA FLJ51746, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG61296.1} B1AP63 [Target identity:50%; Query identity:100%]Lysophosphatidic acid receptor 1 {ECO:0000313|Ensembl:ENSP00000401810}
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Show »
« Hide
G-protein coupled receptors
GPCRs excl olfactory receptors
Lysolipids receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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364 |
41.1 |
No |
7 |
| LPAR1-003 |
ENSP00000351755
ENST00000358883
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Q92633
Show all »
« Hide
Q92633 [Direct mapping]Lysophosphatidic acid receptor 1 Q5VZX0 [Target identity:100%; Query identity:100%]Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a {ECO:0000313|EMBL:EAW59068.1}; cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG51118.1}; cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA {ECO:0000313|EMBL:BAF82976.1} Q6GPG7 [Target identity:95%; Query identity:100%]LPAR1 protein {ECO:0000313|EMBL:AAH73167.1}; cDNA FLJ51746, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG61296.1} B1AP63 [Target identity:50%; Query identity:100%]Lysophosphatidic acid receptor 1 {ECO:0000313|Ensembl:ENSP00000401810}
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Show »
« Hide
G-protein coupled receptors
GPCRs excl olfactory receptors
Lysolipids receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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364 |
41.1 |
No |
7 |
| LPAR1-004 |
ENSP00000401810
ENST00000441240
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B1AP63
Show all »
« Hide
B1AP63 [Target identity:100%; Query identity:100%]Lysophosphatidic acid receptor 1 {ECO:0000313|Ensembl:ENSP00000401810}
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Show »
« Hide
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
# TM segments-based
4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070915 [lysophosphatidic acid receptor activity]
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182 |
20.6 |
No |
4 |
| LPAR1-201 |
ENSP00000445697
ENST00000541779
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Q6GPG7
Show all »
« Hide
Q6GPG7 [Target identity:100%; Query identity:100%]LPAR1 protein {ECO:0000313|EMBL:AAH73167.1}; cDNA FLJ51746, highly similar to Lysophosphatidic acid receptor Edg-2 {ECO:0000313|EMBL:BAG61296.1}
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Show »
« Hide
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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346 |
39.3 |
No |
7 |
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