HIF1A

CANCER ATLAS

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Gene description

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

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HPA001275
 
 
CAB017442
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Malignant tissues exhibited weak to moderate cytoplasmic and/or nuclear immunoreactivity. A few cases of colo-rectal cancers showed strong cytoplasmic staining while some urothelial cancers expressed strong nuclear positivity. Many cases of endometrial, stomach, renal and liver cancers were negative.
 

Level of antibody staining/expression





High
Medium
Low
Not detected