HERC2

CANCER ATLAS

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Gene description

HECT and RLD domain containing E3 ubiquitin protein ligase 2

Protein class

Cytoskeleton related proteins, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

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HPA048389
 
CAB017188
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Most cancers exhibited weak to moderate cytoplasmic staining. Several gliomas along with cases of breast, cervical, endometrial, skin and testis cancers showed strong positivity. Additional nuclear positivity was observed in fractions of cases. Several renal cell carcinomas were negative.
 

Level of antibody staining/expression





High
Medium
Low
Not detected