ALCAM

CANCER ATLAS

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Gene description

Activated leukocyte cell adhesion molecule

Protein class

Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

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HPA010926
 
CAB002148
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

A majority of malignancies showed moderate to strong membranous positivity. Malignant lymphomas, melanomas, testicular and renal cancers were weakly stained or negative. Many malignancies showed big variation in expression with negative, weak, moderate and strong samples within the same tumor type. Malignancies showed similar staining pattern as found in normal cells. Strong membranous staining found in many adenocarcinomas of e.g. colo-rectal, breast, prostate, cervix and endometrium. Gliomas were also mainly strong positive. Lymphomas, melanomas, testis and renal carcinomas were mainly negative. Cytoplasmic staining was also found in many samples but seems to be overstaining in most cases.
 

Level of antibody staining/expression





High
Medium
Low
Not detected