PROTEIN CLASSES

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Function and compartment based

Protein class

No of genes

No of genes with antibodies

Source

Enzymes » 3247 3027
CD markers 373 317 UniProt
Blood group antigen proteins 32 26 UniProt
Nuclear receptors 49 41 NucleaRDB
Transporters » 998 846 TCDB
Ribosomal proteins 150 143 UniProt
G-protein coupled receptors » 769 385 UniProt
Voltage-gated ion channels » 133 100 IUPHAR-DB
Predicted membrane proteins » 5462 4422 MDM
Predicted secreted proteins » 2927 2483 HPA
Predicted intracellular proteins 14936 13360 HPA
Plasma proteins 3761 3493 Plasma Proteome Database
Transcription factors » 1513 1292 UMG
Mitochondrial proteins 777 740 MitoProteome
RNA polymerase related proteins 31 30 KEGG
RAS pathway related proteins 228 200 KEGG
Citric acid cycle related proteins 30 29 KEGG
Cytoskeleton related proteins 451 418 GO


Disease and drug related

Protein class

No of genes

No of genes with antibodies

Source

Cancer-related genes » 1700 1551
Candidate cardiovascular disease genes 162 145 Plasma Proteome Institute
Disease related genes 3365 3002 UniProt
FDA approved drug targets » 625 520 Drugbank
Potential drug targets 1054 952 HPA


Evidence based

Protein class

No of genes

No of genes with antibodies

Source

Mapped to UniProt SWISS-PROT » 18930 16593 UniProt
Protein evidence (Kim et al 2014) 12850 11995 Kim et al 2014
Protein evidence (Ezkurdia et al 2014) 11668 11014 Ezkurdia et al 2014