NFYA

GENE INFORMATION

? »

Gene name

NFYA (HGNC Symbol)

Synonyms

CBF-B, HAP2, NF-YA

Description

Nuclear transcription factor Y, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

41072945 - 41099976

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000001167 (version 78.38)

Entrez gene

4800

UniProt

P23511 (UniProt - Evidence at protein level)

neXtProt

NX_P23511

Antibodypedia

NFYA antibodies
 

PROTEIN VIEW

? »
 
 
 
NFYA-001
 
NFYA-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFYA-001 ENSP00000345702
ENST00000341376
P23511
Show all »
Show » Show » 347 36.9 No 0
NFYA-002 ENSP00000229418
ENST00000353205
P23511
Show all »
Show » Show » 318 33.9 No 0