ITGAL

GENE INFORMATION

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Gene name

ITGAL (HGNC Symbol)

Synonyms

CD11A, LFA-1

Description

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (HGNC Symbol)

Entrez gene summary

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

30472658 - 30523185

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005844 (version 78.38)

Entrez gene

3683

UniProt

P20701 (UniProt - Evidence at protein level)

neXtProt

NX_P20701

Antibodypedia

ITGAL antibodies
 

PROTEIN VIEW

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ITGAL-001
 
ITGAL-002
 
ITGAL-004
 
ITGAL-007
 
ITGAL-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGAL-001 ENSP00000349252
ENST00000356798
P20701
Show all »
Show » Show » 1170 128.8 Yes 1
ITGAL-002 ENSP00000350886
ENST00000358164
P20701
Show all »
Show » Show » 1086 119.2 Yes 1
ITGAL-004 ENSP00000409377
ENST00000433423
B4E021
Show all »
Show » Show » 404 44.8 Yes 1
ITGAL-007 ENSP00000456888
ENST00000564118
H3BSV1
Show all »
Show » 204 22 Yes 0
ITGAL-008 ENSP00000461006
ENST00000569725
I3L468
Show all »
Show » 41 4.5 No 0