ETV1

GENE INFORMATION

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Gene name

ETV1 (HGNC Symbol)

Synonyms

ER81

Description

Ets variant 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

7

Cytoband

p21.2

Chromosome location (bp)

13891228 - 13991425

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000006468 (version 78.38)

Entrez gene

2115

UniProt

P50549 (UniProt - Evidence at protein level)

neXtProt

NX_P50549

Antibodypedia

ETV1 antibodies
 

PROTEIN VIEW

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 « 
 
ETV1-001
 
ETV1-003
 
ETV1-004
 
ETV1-005
 
ETV1-007
 
ETV1-008
 
ETV1-009
 
ETV1-011
 
ETV1-012
 
ETV1-014
 
ETV1-020
 
ETV1-201
 
ETV1-202
 
ETV1-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ETV1-001 ENSP00000405327
ENST00000430479
P50549
Show all »
Show » Show » 477 55.1 No 0
ETV1-003 ENSP00000385686
ENST00000403685
P50549
Show all »
Show » Show » 459 53.1 No 0
ETV1-004 ENSP00000385551
ENST00000405218
P50549
Show all »
Show » Show » 477 55.1 No 0
ETV1-005 ENSP00000385381
ENST00000405192
P50549
Show all »
Show » Show » 454 52.5 No 0
ETV1-007 ENSP00000384085
ENST00000405358
B5MCT2
Show all »
Show » Show » 491 56.5 No 0
ETV1-008 ENSP00000384138
ENST00000403527
P50549
Show all »
Show » Show » 437 50.2 No 0
ETV1-009 ENSP00000393078
ENST00000438956
C9JX69
Show all »
Show » Show » 288 32.7 No 0
ETV1-011 ENSP00000391043
ENST00000421381
C9J4P4
Show all »
Show » Show » 123 14.2 No 0
ETV1-012 ENSP00000410819
ENST00000431887
C9J9L1
Show all »
Show » Show » 95 11.1 No 0
ETV1-014 ENSP00000406931
ENST00000433547
C9J0B7
Show all »
Show » 20 2.4 No 0
ETV1-020 ENSP00000394710
ENST00000443608
C9JQH6
Show all »
Show » Show » 173 19.8 No 0
ETV1-201 ENSP00000242066
ENST00000242066
P50549
Show all »
Show » Show » 459 53.1 No 0
ETV1-202 ENSP00000382293
ENST00000399357
P50549
Show all »
Show » Show » 374 43.5 No 0
ETV1-203 ENSP00000411626
ENST00000420159
P50549
Show all »
Show » Show » 419 48.2 No 0