E2F2

GENE INFORMATION

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Gene name

E2F2 (HGNC Symbol)

Synonyms

E2F-2

Description

E2F transcription factor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

23506430 - 23531220

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000007968 (version 78.38)

Entrez gene

1870

UniProt

Q14209 (UniProt - Evidence at protein level)

neXtProt

NX_Q14209

Antibodypedia

E2F2 antibodies
 

PROTEIN VIEW

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E2F2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F2-001 ENSP00000355249
ENST00000361729
Q14209
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