HFE - Gene info - The Human Protein Atlas

HFE

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	HFE (HGNC Symbol)
Synonyms	HLA-H
Description	Hemochromatosis (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26087281 - 26098343
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010704 (version 78.38)
Entrez gene	3077
UniProt	Q30201 (UniProt - Evidence at protein level)
neXtProt	NX_Q30201
Antibodypedia	HFE antibodies

PROTEIN VIEW

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HFE-001		HFE-003		HFE-004		HFE-005		HFE-006		HFE-007		HFE-011		HFE-012		HFE-014		HFE-015		HFE-019		HFE-024

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
HFE-001	ENSP00000417404 ENST00000357618	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein Q86WL1 [Target identity:77%; Query identity:100%] Hemochromatosis {ECO:0000313\|EMBL:AAO47091.1} Q9UK37 [Target identity:37%; Query identity:100%] Hereditary haemochromatosis protein {ECO:0000313\|EMBL:AAF01222.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAM91950.1} Q9BXI5 [Target identity:26%; Query identity:100%] Hemochromatosis protein E1_4A_B022 {ECO:0000313\|EMBL:AFI39675.1}; Hemochromatosis protein E2_4A_B023 {ECO:0000313\|EMBL:AFI39676.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAK16502.1} Q8MH46 [Target identity:26%; Query identity:100%] Hereditary hemochromatosis protein HLA-H {ECO:0000313\|EMBL:AAM82608.1} I1VA72 [Target identity:26%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} I1VA60 [Target identity:25%; Query identity:100%] Hemochromatosis protein E2_3B_B021 {ECO:0000313\|EMBL:AFI39674.1} F5B2M9 [Target identity:25%; Query identity:100%] HFE {ECO:0000313\|EMBL:AEB15974.1} G3LGR1 [Target identity:24%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} G3LGR0 [Target identity:24%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGQ9 [Target identity:23%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} I1VA63 [Target identity:22%; Query identity:100%] Hemochromatosis protein E1_4B_B024 {ECO:0000313\|EMBL:AFI39677.1}; Hemochromatosis protein E2_4B_B025 {ECO:0000313\|EMBL:AFI39678.1} G3LGQ6 [Target identity:19%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50367.1} I1VA56 [Target identity:14%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} I1VA66 [Target identity:8%; Query identity:100%] Hemochromatosis protein E2_4C_B027 {ECO:0000313\|EMBL:AFI39680.1} I1VA55 [Target identity:7%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1} H2E8T5 [Target identity:7%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0007565 [female pregnancy] GO:0010106 [cellular response to iron ion starvation] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042446 [hormone biosynthetic process] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055072 [iron ion homeostasis] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0097459 [iron ion import into cell]	348	40.1	Yes	1
HFE-003	ENSP00000315936 ENST00000352392	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein H2E8T5 [Target identity:32%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	76	8.2	Yes	1
HFE-004	ENSP00000259699 ENST00000349999	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein Q9UK37 [Target identity:49%; Query identity:100%] Hereditary haemochromatosis protein {ECO:0000313\|EMBL:AAF01222.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAM91950.1} I1VA72 [Target identity:35%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} Q8MH46 [Target identity:35%; Query identity:100%] Hereditary hemochromatosis protein HLA-H {ECO:0000313\|EMBL:AAM82608.1} Q9BXI5 [Target identity:35%; Query identity:100%] Hemochromatosis protein E1_4A_B022 {ECO:0000313\|EMBL:AFI39675.1}; Hemochromatosis protein E2_4A_B023 {ECO:0000313\|EMBL:AFI39676.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAK16502.1} G3LGR1 [Target identity:33%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} I1VA60 [Target identity:33%; Query identity:100%] Hemochromatosis protein E2_3B_B021 {ECO:0000313\|EMBL:AFI39674.1} G3LGR0 [Target identity:32%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGQ9 [Target identity:31%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} I1VA63 [Target identity:30%; Query identity:100%] Hemochromatosis protein E1_4B_B024 {ECO:0000313\|EMBL:AFI39677.1}; Hemochromatosis protein E2_4B_B025 {ECO:0000313\|EMBL:AFI39678.1} I1VA66 [Target identity:11%; Query identity:100%] Hemochromatosis protein E2_4C_B027 {ECO:0000313\|EMBL:AFI39680.1} H2E8T5 [Target identity:9%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	260	29.6	Yes	1
HFE-005	ENSP00000380217 ENST00000397022	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein Q86WL1 [Target identity:82%; Query identity:100%] Hemochromatosis {ECO:0000313\|EMBL:AAO47091.1} Q9UK37 [Target identity:39%; Query identity:100%] Hereditary haemochromatosis protein {ECO:0000313\|EMBL:AAF01222.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAM91950.1} I1VA72 [Target identity:28%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} Q8MH46 [Target identity:28%; Query identity:100%] Hereditary hemochromatosis protein HLA-H {ECO:0000313\|EMBL:AAM82608.1} Q9BXI5 [Target identity:28%; Query identity:100%] Hemochromatosis protein E1_4A_B022 {ECO:0000313\|EMBL:AFI39675.1}; Hemochromatosis protein E2_4A_B023 {ECO:0000313\|EMBL:AFI39676.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAK16502.1} G3LGR1 [Target identity:26%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} I1VA60 [Target identity:26%; Query identity:100%] Hemochromatosis protein E2_3B_B021 {ECO:0000313\|EMBL:AFI39674.1} G3LGR0 [Target identity:25%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGQ9 [Target identity:24%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} I1VA63 [Target identity:24%; Query identity:100%] Hemochromatosis protein E1_4B_B024 {ECO:0000313\|EMBL:AFI39677.1}; Hemochromatosis protein E2_4B_B025 {ECO:0000313\|EMBL:AFI39678.1} I1VA56 [Target identity:15%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} I1VA66 [Target identity:9%; Query identity:100%] Hemochromatosis protein E2_4C_B027 {ECO:0000313\|EMBL:AFI39680.1} I1VA55 [Target identity:8%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1} H2E8T5 [Target identity:7%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	325	37.5	Yes	1
HFE-006	ENSP00000313776 ENST00000317896	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein Q9UK37 [Target identity:50%; Query identity:100%] Hereditary haemochromatosis protein {ECO:0000313\|EMBL:AAF01222.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAM91950.1} Q8MH46 [Target identity:35%; Query identity:100%] Hereditary hemochromatosis protein HLA-H {ECO:0000313\|EMBL:AAM82608.1} Q9BXI5 [Target identity:35%; Query identity:100%] Hemochromatosis protein E1_4A_B022 {ECO:0000313\|EMBL:AFI39675.1}; Hemochromatosis protein E2_4A_B023 {ECO:0000313\|EMBL:AFI39676.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAK16502.1} F5B2M9 [Target identity:33%; Query identity:100%] HFE {ECO:0000313\|EMBL:AEB15974.1} G3LGR1 [Target identity:33%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} I1VA60 [Target identity:33%; Query identity:100%] Hemochromatosis protein E2_3B_B021 {ECO:0000313\|EMBL:AFI39674.1} G3LGR0 [Target identity:32%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGQ9 [Target identity:31%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} I1VA63 [Target identity:30%; Query identity:100%] Hemochromatosis protein E1_4B_B024 {ECO:0000313\|EMBL:AFI39677.1}; Hemochromatosis protein E2_4B_B025 {ECO:0000313\|EMBL:AFI39678.1} G3LGQ6 [Target identity:26%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50367.1} I1VA56 [Target identity:19%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} I1VA66 [Target identity:12%; Query identity:100%] Hemochromatosis protein E2_4C_B027 {ECO:0000313\|EMBL:AFI39680.1} I1VA55 [Target identity:10%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1} H2E8T5 [Target identity:9%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	256	29.2	Yes	1
HFE-007	ENSP00000312342 ENST00000353147	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein Q9UK37 [Target identity:76%; Query identity:100%] Hereditary haemochromatosis protein {ECO:0000313\|EMBL:AAF01222.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAM91950.1} Q8MH46 [Target identity:54%; Query identity:100%] Hereditary hemochromatosis protein HLA-H {ECO:0000313\|EMBL:AAM82608.1} Q9BXI5 [Target identity:54%; Query identity:100%] Hemochromatosis protein E1_4A_B022 {ECO:0000313\|EMBL:AFI39675.1}; Hemochromatosis protein E2_4A_B023 {ECO:0000313\|EMBL:AFI39676.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAK16502.1} G3LGR1 [Target identity:51%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} I1VA60 [Target identity:51%; Query identity:100%] Hemochromatosis protein E2_3B_B021 {ECO:0000313\|EMBL:AFI39674.1} G3LGR0 [Target identity:50%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGQ9 [Target identity:48%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} I1VA63 [Target identity:47%; Query identity:100%] Hemochromatosis protein E1_4B_B024 {ECO:0000313\|EMBL:AFI39677.1}; Hemochromatosis protein E2_4B_B025 {ECO:0000313\|EMBL:AFI39678.1} I1VA66 [Target identity:18%; Query identity:100%] Hemochromatosis protein E2_4C_B027 {ECO:0000313\|EMBL:AFI39680.1} H2E8T5 [Target identity:14%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	168	18.7	Yes	1
HFE-011	ENSP00000419725 ENST00000470149	Q6B0J5 Show all » « Hide Q6B0J5 [Target identity:100%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AAH74721.1}; Hereditary hemochromatosis protein {ECO:0000313\|Ensembl:ENSP00000419725} I1VA72 [Target identity:26%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} F5B2M9 [Target identity:25%; Query identity:100%] HFE {ECO:0000313\|EMBL:AEB15974.1} G3LGR0 [Target identity:24%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGR1 [Target identity:24%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} G3LGQ9 [Target identity:23%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} G3LGQ6 [Target identity:20%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50367.1} I1VA56 [Target identity:14%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} H2E8T5 [Target identity:7%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1} I1VA55 [Target identity:7%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]	345	39.7	Yes	1
HFE-012	ENSP00000337819 ENST00000336625	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein F5B2M9 [Target identity:35%; Query identity:100%] HFE {ECO:0000313\|EMBL:AEB15974.1} G3LGR1 [Target identity:35%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} G3LGR0 [Target identity:34%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGQ9 [Target identity:33%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} G3LGQ6 [Target identity:28%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50367.1} I1VA56 [Target identity:20%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} I1VA55 [Target identity:11%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1} H2E8T5 [Target identity:10%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	242	27.7	Yes	1
HFE-014	ENSP00000420802 ENST00000461397	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein I1VA72 [Target identity:27%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} F5B2M9 [Target identity:26%; Query identity:100%] HFE {ECO:0000313\|EMBL:AEB15974.1} G3LGR0 [Target identity:25%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGR1 [Target identity:25%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} G3LGQ9 [Target identity:24%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} G3LGQ6 [Target identity:20%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50367.1} I1VA56 [Target identity:14%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} I1VA55 [Target identity:8%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1} H2E8T5 [Target identity:7%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	334	38.6	Yes	1
HFE-015	ENSP00000420559 ENST00000488199	Q30201 Show all » « Hide Q30201 [Direct mapping] Hereditary hemochromatosis protein I1VA72 [Target identity:36%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} G3LGR0 [Target identity:34%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50371.1} G3LGR1 [Target identity:34%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50372.1} G3LGQ9 [Target identity:32%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50370.1} H2E8T5 [Target identity:10%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0019882 [antigen processing and presentation] GO:0031410 [cytoplasmic vesicle] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0097459 [iron ion import into cell]	246	28.2	Yes	1
HFE-019	ENSP00000311698 ENST00000309234	F8W7W8 Show all » « Hide F8W7W8 [Target identity:100%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|Ensembl:ENSP00000311698} Q9UK37 [Target identity:38%; Query identity:100%] Hereditary haemochromatosis protein {ECO:0000313\|EMBL:AAF01222.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAM91950.1} I1VA72 [Target identity:27%; Query identity:100%] Hemochromatosis protein E1_3B_B020 {ECO:0000313\|EMBL:AFI39673.1}; Hemochromatosis protein E2_3A_B038 {ECO:0000313\|EMBL:AFI39686.1} Q8MH46 [Target identity:27%; Query identity:100%] Hereditary hemochromatosis protein HLA-H {ECO:0000313\|EMBL:AAM82608.1} Q9BXI5 [Target identity:27%; Query identity:100%] Hemochromatosis protein E1_4A_B022 {ECO:0000313\|EMBL:AFI39675.1}; Hemochromatosis protein E2_4A_B023 {ECO:0000313\|EMBL:AFI39676.1}; Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AAK16502.1} F5B2M9 [Target identity:25%; Query identity:100%] HFE {ECO:0000313\|EMBL:AEB15974.1} I1VA60 [Target identity:25%; Query identity:100%] Hemochromatosis protein E2_3B_B021 {ECO:0000313\|EMBL:AFI39674.1} I1VA63 [Target identity:23%; Query identity:100%] Hemochromatosis protein E1_4B_B024 {ECO:0000313\|EMBL:AFI39677.1}; Hemochromatosis protein E2_4B_B025 {ECO:0000313\|EMBL:AFI39678.1} G3LGQ6 [Target identity:20%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|EMBL:AEO50367.1} I1VA56 [Target identity:14%; Query identity:100%] Hemochromatosis protein E2_2A_B017 {ECO:0000313\|EMBL:AFI39670.1} I1VA66 [Target identity:9%; Query identity:100%] Hemochromatosis protein E2_4C_B027 {ECO:0000313\|EMBL:AFI39680.1} I1VA55 [Target identity:8%; Query identity:100%] Hemochromatosis protein E1_2A_B016 {ECO:0000313\|EMBL:AFI39669.1} H2E8T5 [Target identity:7%; Query identity:100%] HFE protein {ECO:0000313\|EMBL:AEX91880.1}; Hemochromatosis {ECO:0000313\|EMBL:AEX30808.1}; Hemochromatosis protein E1A_B010 {ECO:0000313\|EMBL:AFI39663.1}; Hemochromatosis protein E1_1B_B012 {ECO:0000313\|EMBL:AFI39665.1}; Hemochromatosis protein E2A_B011 {ECO:0000313\|EMBL:AFI39664.1}; Hemochromatosis protein E2_1B_B013 {ECO:0000313\|EMBL:AFI39666.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]	337	38.9	Yes	1
HFE-024	ENSP00000417534 ENST00000485729	H7C4K4 Show all » « Hide H7C4K4 [Target identity:100%; Query identity:100%] Hereditary hemochromatosis protein {ECO:0000313\|Ensembl:ENSP00000417534}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)		55	6	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.