PIK3C2A

GENE INFORMATION

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Gene name

PIK3C2A (HGNC Symbol)

Synonyms

PI3K-C2alpha

Description

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.1

Chromosome location (bp)

17077730 - 17207983

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000011405 (version 78.38)

Entrez gene

5286

UniProt

O00443 (UniProt - Evidence at protein level)

neXtProt

NX_O00443

Antibodypedia

PIK3C2A antibodies
 

PROTEIN VIEW

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PIK3C2A-001
 
PIK3C2A-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIK3C2A-001 ENSP00000265970
ENST00000265970
O00443
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Show » Show » 1686 190.7 No 0
PIK3C2A-005 ENSP00000436969
ENST00000532035
E9PPP3
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Show » Show » 130 14.6 No 0