PLAUR

GENE INFORMATION

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Gene name

PLAUR (HGNC Symbol)

Synonyms

CD87, UPAR, URKR

Description

Plasminogen activator, urokinase receptor (HGNC Symbol)

Entrez gene summary

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.31

Chromosome location (bp)

43646095 - 43670547

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000011422 (version 78.38)

Entrez gene

5329

UniProt

Q03405 (UniProt - Evidence at protein level)

neXtProt

NX_Q03405

Antibodypedia

PLAUR antibodies
 

PROTEIN VIEW

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 « 
 
PLAUR-001
 
PLAUR-002
 
PLAUR-003
 
PLAUR-006
 
PLAUR-007
 
PLAUR-008
 
PLAUR-009
 
PLAUR-010
 
PLAUR-011
 
PLAUR-012
 
PLAUR-014
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLAUR-001 ENSP00000339328
ENST00000340093
Q03405
Show all »
Show » Show » 335 37 Yes 1
PLAUR-002 ENSP00000221264
ENST00000221264
Q03405
Show all »
Show » Show » 290 32 Yes 1
PLAUR-003 ENSP00000342049
ENST00000339082
Q03405
Show all »
Show » Show » 281 31.3 Yes 0
PLAUR-006 ENSP00000470029
ENST00000599892
M0QYR6
Show all »
Show » 226 25.2 No 0
PLAUR-007 ENSP00000472511
ENST00000593939
M0R2E9
Show all »
Show » Show » 152 17.2 No 0
PLAUR-008 ENSP00000468863
ENST00000599546
M0QX27
Show all »
Show » 78 8.9 No 0
PLAUR-009 ENSP00000471241
ENST00000602141
M0R0H5
Show all »
Show » 153 17.1 No 0
PLAUR-010 ENSP00000473055
ENST00000595038
Show » 154 16.8 No 0
PLAUR-011 ENSP00000470050
ENST00000593447
Show » 133 14.9 No 0
PLAUR-012 ENSP00000471881
ENST00000601723
M0R1I2
Show all »
Show » 286 31.6 Yes 1
PLAUR-014 ENSP00000471525
ENST00000593714
Show » 185 20.6 No 0