NR1H3 - Gene info - The Human Protein Atlas

NR1H3

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NR1H3 (HGNC Symbol)
Synonyms	LXR-a, RLD-1
Description	Nuclear receptor subfamily 1, group H, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	47248300 - 47269032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000025434 (version 78.38)
Entrez gene	10062
UniProt	Q13133 (UniProt - Evidence at protein level)
neXtProt	NX_Q13133
Antibodypedia	NR1H3 antibodies

PROTEIN VIEW

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NR1H3-001		NR1H3-002		NR1H3-003		NR1H3-006		NR1H3-007		NR1H3-010		NR1H3-011		NR1H3-012		NR1H3-013		NR1H3-016		NR1H3-017		NR1H3-023		NR1H3-030		NR1H3-031		NR1H3-032		NR1H3-037		NR1H3-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NR1H3-001	ENSP00000420656 ENST00000467728	Q13133 Show all » « Hide Q13133 [Direct mapping] Oxysterols receptor LXR-alpha F1D8N1 [Target identity:100%; Query identity:100%] Liver X nuclear receptor alpha variant 1 {ECO:0000313\|EMBL:ADZ17330.1} C9JBS2 [Target identity:47%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403696} C9JCS0 [Target identity:45%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000415591} C9JJ16 [Target identity:45%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:43%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:29%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:17%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:15%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:2000188 [regulation of cholesterol homeostasis] GO:2000189 [positive regulation of cholesterol homeostasis]	447	50.4	No	0
NR1H3-002	ENSP00000385801 ENST00000407404	Q13133 Show all » « Hide Q13133 [Direct mapping] Oxysterols receptor LXR-alpha B5MBY7 [Target identity:88%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000385073} E9PID2 [Target identity:76%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000432073} C9JBS2 [Target identity:54%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403696} C9JCS0 [Target identity:52%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000415591} C9JJ16 [Target identity:52%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:49%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:34%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:19%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:17%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:2000188 [regulation of cholesterol homeostasis] GO:2000189 [positive regulation of cholesterol homeostasis]	387	43.6	No	0
NR1H3-003	ENSP00000385073 ENST00000405576	B5MBY7 Show all » « Hide B5MBY7 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000385073} E9PID2 [Target identity:86%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000432073} C9J2C8 [Target identity:39%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	342	38.9	No	0
NR1H3-006	ENSP00000384745 ENST00000405853	Q13133 Show all » « Hide Q13133 [Direct mapping] Oxysterols receptor LXR-alpha B5MBY7 [Target identity:88%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000385073} E9PID2 [Target identity:76%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000432073} C9JBS2 [Target identity:54%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403696} C9JCS0 [Target identity:52%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000415591} C9JJ16 [Target identity:52%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:49%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:34%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:19%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:17%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:2000188 [regulation of cholesterol homeostasis] GO:2000189 [positive regulation of cholesterol homeostasis]	387	43.6	No	0
NR1H3-007	ENSP00000403798 ENST00000436778	C9JJ16 Show all » « Hide C9JJ16 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:95%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:66%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:38%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:33%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	202	22	No	0
NR1H3-010	ENSP00000391005 ENST00000444396	C9J4R0 Show all » « Hide C9J4R0 [Target identity:99%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:69%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:39%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:35%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	194	21.2	No	0
NR1H3-011	ENSP00000413095 ENST00000457932	C9JTS4 Show all » « Hide C9JTS4 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:88%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Predicted intracellular proteins		77	7.8	No	0
NR1H3-012	ENSP00000412636 ENST00000412937	C9J2C8 Show all » « Hide C9J2C8 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]	134	14.8	No	0
NR1H3-013	ENSP00000415591 ENST00000449369	C9JCS0 Show all » « Hide C9JCS0 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000415591} C9JJ16 [Target identity:98%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:94%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:65%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:37%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:33%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	205	22.4	No	0
NR1H3-016	ENSP00000403696 ENST00000436029	C9JBS2 Show all » « Hide C9JBS2 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403696} C9JCS0 [Target identity:96%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000415591} C9JJ16 [Target identity:95%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:91%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:63%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:36%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:32%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	212	23.1	No	0
NR1H3-017	ENSP00000396132 ENST00000437276	C9JEC2 Show all » « Hide C9JEC2 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Predicted intracellular proteins		68	6.9	No	0
NR1H3-023	ENSP00000433271 ENST00000481889	E9PLL4 Show all » « Hide E9PLL4 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000433271} C9J2C8 [Target identity:28%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	466	52.8	No	0
NR1H3-030	ENSP00000387946 ENST00000441012	Q13133 Show all » « Hide Q13133 [Direct mapping] Oxysterols receptor LXR-alpha F1D8N1 [Target identity:100%; Query identity:100%] Liver X nuclear receptor alpha variant 1 {ECO:0000313\|EMBL:ADZ17330.1} C9JBS2 [Target identity:47%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403696} C9JCS0 [Target identity:45%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000415591} C9JJ16 [Target identity:45%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000403798} C9J4R0 [Target identity:43%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000391005} C9J2C8 [Target identity:29%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636} C9JTS4 [Target identity:17%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000413095} C9JEC2 [Target identity:15%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000396132}	Show » « Hide Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:2000188 [regulation of cholesterol homeostasis] GO:2000189 [positive regulation of cholesterol homeostasis]	447	50.4	No	0
NR1H3-031	ENSP00000378793 ENST00000395397	Q13133 Show all » « Hide Q13133 [Direct mapping] Oxysterols receptor LXR-alpha C9J2C8 [Target identity:33%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636}	Show » « Hide Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:2000188 [regulation of cholesterol homeostasis] GO:2000189 [positive regulation of cholesterol homeostasis]	402	45.7	No	0
NR1H3-032	ENSP00000432073 ENST00000527949	E9PID2 Show all » « Hide E9PID2 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000432073}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	296	34.1	No	0
NR1H3-037	ENSP00000434650 ENST00000531660	E9PPA1 Show all » « Hide E9PPA1 [Target identity:100%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000434650}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043401 [steroid hormone mediated signaling pathway]	167	18.6	No	0
NR1H3-201	ENSP00000477707 ENST00000616973	B4DXU5 Show all » « Hide B4DXU5 [Target identity:100%; Query identity:100%] cDNA FLJ56172, highly similar to Oxysterols receptor LXR-alpha {ECO:0000313\|EMBL:BAG63507.1} C9J2C8 [Target identity:29%; Query identity:100%] Oxysterols receptor LXR-alpha {ECO:0000313\|Ensembl:ENSP00000412636}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0030522 [intracellular receptor signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0043031 [negative regulation of macrophage activation] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050728 [negative regulation of inflammatory response] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:2000188 [regulation of cholesterol homeostasis]	453	51.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.