MYOC

GENE INFORMATION

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Gene name

MYOC (HGNC Symbol)

Synonyms

GLC1A, JOAG1, TIGR

Description

Myocilin, trabecular meshwork inducible glucocorticoid response (HGNC Symbol)

Entrez gene summary

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q24.3

Chromosome location (bp)

171635417 - 171652683

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000034971 (version 78.38)

Entrez gene

4653

UniProt

Q99972 (UniProt - Evidence at protein level)

neXtProt

NX_Q99972

Antibodypedia

MYOC antibodies
 

PROTEIN VIEW

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MYOC-001
 
MYOC-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYOC-001 ENSP00000037502
ENST00000037502
Q99972
Show all »
Show » Show » 504 57 Yes 0
MYOC-201 ENSP00000478680
ENST00000614688
B6V6K7
Show all »
Show » Show » 344 38.9 Yes 0