TG

GENE INFORMATION

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Gene name

TG (HGNC Symbol)

Synonyms

AITD3, TGN

Description

Thyroglobulin (HGNC Symbol)

Entrez gene summary

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Chromosome

8

Cytoband

q24.22

Chromosome location (bp)

132866958 - 133134903

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000042832 (version 78.38)

Entrez gene

7038

UniProt

P01266 (UniProt - Evidence at protein level)

neXtProt

NX_P01266

Antibodypedia

TG antibodies
 

PROTEIN VIEW

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TG-001
 
TG-003
 
TG-004
 
TG-005
 
TG-007
 
TG-010
 
TG-017
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TG-001 ENSP00000220616
ENST00000220616
P01266
Show all »
Show » Show » 2768 304.8 Yes 0
TG-003 ENSP00000430523
ENST00000519178
Q9NYD9
Show all »
Show » 1224 134.6 No 0
TG-004 ENSP00000429164
ENST00000518058
Show » 62 6.6 No 0
TG-005 ENSP00000430430
ENST00000519543
E7EVM0
Show all »
Show » 901 99.4 No 0
TG-007 ENSP00000430161
ENST00000521107
H0YBR7
Show all »
Show » 172 19.3 No 0
TG-010 ENSP00000429761
ENST00000518108
Show » 194 20.9 No 0
TG-017 ENSP00000429605
ENST00000518505
Show » 226 23.7 No 0