POLR2B

GENE INFORMATION

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Gene name

POLR2B (HGNC Symbol)

Synonyms

RPB2

Description

Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa (HGNC Symbol)

Entrez gene summary

This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

4

Cytoband

q12

Chromosome location (bp)

56977722 - 57031168

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000047315 (version 78.38)

Entrez gene

5431

UniProt

P30876 (UniProt - Evidence at protein level)

neXtProt

NX_P30876

Antibodypedia

POLR2B antibodies
 

PROTEIN VIEW

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POLR2B-001
 
POLR2B-003
 
POLR2B-005
 
POLR2B-006
 
POLR2B-014
 
POLR2B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLR2B-001 ENSP00000370625
ENST00000381227
P30876
Show all »
Show » Show » 1174 133.9 No 0
POLR2B-003 ENSP00000408638
ENST00000450656
C9JMN3
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Show » Show » 64 7.6 No 0
POLR2B-005 ENSP00000407728
ENST00000433463
C9JZW8
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Show » Show » 76 8.8 No 0
POLR2B-006 ENSP00000391452
ENST00000441246
C9J2Y9
Show all »
Show » Show » 1167 133.1 No 0
POLR2B-014 ENSP00000391096
ENST00000431623
C9J4M6
Show all »
Show » Show » 1099 125.2 No 0
POLR2B-201 ENSP00000312735
ENST00000314595
P30876
Show all »
Show » Show » 1174 133.9 No 0