RRM2B

GENE INFORMATION

? »

Gene name

RRM2B (HGNC Symbol)

Synonyms

p53R2

Description

Ribonucleotide reductase M2 B (TP53 inducible) (HGNC Symbol)

Entrez gene summary

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Chromosome

8

Cytoband

q22.3

Chromosome location (bp)

102204502 - 102239118

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000048392 (version 78.38)

Entrez gene

50484

UniProt

Q7LG56 (UniProt - Evidence at protein level)

neXtProt

NX_Q7LG56

Antibodypedia

RRM2B antibodies
 

PROTEIN VIEW

? »
 
 
 
RRM2B-001
 
RRM2B-002
 
RRM2B-003
 
RRM2B-004
 
RRM2B-005
 
RRM2B-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RRM2B-001 ENSP00000251810
ENST00000251810
Q7LG56
Show all »
Show » Show » 351 40.7 No 1
RRM2B-002 ENSP00000429140
ENST00000519962
Q7LG56
Show all »
Show » Show » 66 7.6 No 0
RRM2B-003 ENSP00000428115
ENST00000522368
Show » Show » 408 47 No 1
RRM2B-004 ENSP00000430641
ENST00000519317
Q7LG56
Show all »
Show » Show » 139 16 No 0
RRM2B-005 ENSP00000379248
ENST00000395912
Q7LG56
Show all »
Show » Show » 299 34.5 No 1
RRM2B-201 ENSP00000484318
ENST00000621845
Q7LG56
Show all »
Show » Show » 297 34.5 No 1