HERPUD1

GENE INFORMATION

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Gene name

HERPUD1 (HGNC Symbol)

Synonyms

HERP, KIAA0025, Mif1, SUP

Description

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HGNC Symbol)

Entrez gene summary

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

Chromosome

16

Cytoband

q13

Chromosome location (bp)

56932048 - 56944863

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000051108 (version 78.38)

Entrez gene

9709

UniProt

Q15011 (UniProt - Evidence at protein level)

neXtProt

NX_Q15011

Antibodypedia

HERPUD1 antibodies
 

PROTEIN VIEW

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HERPUD1-001
 
HERPUD1-002
 
HERPUD1-003
 
HERPUD1-004
 
HERPUD1-012
 
HERPUD1-013
 
HERPUD1-014
 
HERPUD1-016
 
HERPUD1-019
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HERPUD1-001 ENSP00000409555
ENST00000439977
Q15011
Show all »
Show » Show » 391 43.7 No 2
HERPUD1-002 ENSP00000300302
ENST00000300302
Q15011
Show all »
Show » Show » 390 43.6 No 2
HERPUD1-003 ENSP00000369118
ENST00000379792
Q15011
Show all »
Show » Show » 366 40.9 No 2
HERPUD1-004 ENSP00000340931
ENST00000344114
Q15011
Show all »
Show » Show » 232 26.2 No 0
HERPUD1-012 ENSP00000457321
ENST00000569429
H3BTT7
Show all »
Show » Show » 150 16.6 No 0
HERPUD1-013 ENSP00000455094
ENST00000563343
H3BP08
Show all »
Show » Show » 160 18 No 0
HERPUD1-014 ENSP00000457955
ENST00000568651
Show » 150 17.1 No 1
HERPUD1-016 ENSP00000455841
ENST00000563911
Show » 226 24.5 No 1
HERPUD1-019 ENSP00000457095
ENST00000568358
Show » 109 12.3 No 0