MXD1

GENE INFORMATION

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Gene name

MXD1 (HGNC Symbol)

Synonyms

bHLHc58, MAD, MAD1

Description

MAX dimerization protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Chromosome

2

Cytoband

p13.3

Chromosome location (bp)

69897688 - 69942945

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000059728 (version 78.38)

Entrez gene

4084

UniProt

Q05195 (UniProt - Evidence at protein level)

neXtProt

NX_Q05195

Antibodypedia

MXD1 antibodies
 

PROTEIN VIEW

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MXD1-001
 
MXD1-002
 
MXD1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MXD1-001 ENSP00000264444
ENST00000264444
Q05195
Show all »
Show » Show » 221 25.3 No 0
MXD1-002 ENSP00000410672
ENST00000435990
C9JBE8
Show all »
Show » Show » 181 20.8 No 0
MXD1-201 ENSP00000443935
ENST00000540449
Q05195
Show all »
Show » Show » 211 24 No 0