TNK2

GENE INFORMATION

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Gene name

TNK2 (HGNC Symbol)

Synonyms

ACK, ACK1, p21cdc42Hs

Description

Tyrosine kinase, non-receptor, 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q29

Chromosome location (bp)

195863364 - 195911945

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000061938 (version 78.38)

Entrez gene

10188

UniProt

Q07912 (UniProt - Evidence at protein level)

neXtProt

NX_Q07912

Antibodypedia

TNK2 antibodies
 

PROTEIN VIEW

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TNK2-002
 
TNK2-005
 
TNK2-007
 
TNK2-010
 
TNK2-012
 
TNK2-014
 
TNK2-016
 
TNK2-019
 
TNK2-020
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNK2-002 ENSP00000329425
ENST00000333602
Q07912
Show all »
Show » Show » 1038 114.6 No 0
TNK2-005 ENSP00000371341
ENST00000381916
Q07912
Show all »
Show » Show » 1086 119.3 No 0
TNK2-007 ENSP00000392546
ENST00000428187
C9J1X3
Show all »
Show » Show » 1040 115 No 0
TNK2-010 ENSP00000398614
ENST00000416152
H0Y5H7
Show all »
Show » Show » 607 65.3 No 0
TNK2-012 ENSP00000390088
ENST00000427576
C9JIR5
Show all »
Show » 143 16.4 No 0
TNK2-014 ENSP00000395154
ENST00000433111
C9JDG3
Show all »
Show » 97 11.6 No 0
TNK2-016 ENSP00000392253
ENST00000438207
Show » Show » 290 33.6 No 0
TNK2-019 ENSP00000415126
ENST00000411741
H7C412
Show all »
Show » Show » 200 21.6 No 0
TNK2-020 ENSP00000390435
ENST00000424563
Show » Show » 242 26.3 No 0