WISP2

GENE INFORMATION

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Gene name

WISP2 (HGNC Symbol)

Synonyms

CCN5, CT58, CTGF-L

Description

WNT1 inducible signaling pathway protein 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44714844 - 44728509

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064205 (version 78.38)

Entrez gene

8839

UniProt

O76076 (UniProt - Evidence at protein level)

neXtProt

NX_O76076

Antibodypedia

WISP2 antibodies
 

PROTEIN VIEW

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WISP2-001
 
WISP2-002
 
WISP2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WISP2-001 ENSP00000190983
ENST00000190983
O76076
Show all »
Show » Show » 250 26.8 Yes 0
WISP2-002 ENSP00000361959
ENST00000372868
O76076
Show all »
Show » Show » 250 26.8 Yes 0
WISP2-003 ENSP00000361956
ENST00000372865
O76076
Show all »
Show » Show » 218 22.6 Yes 0