RASSF1

GENE INFORMATION

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Gene name

RASSF1 (HGNC Symbol)

Synonyms

123F2, NORE2A, RDA32, REH3P21

Description

Ras association (RalGDS/AF-6) domain family member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

50329782 - 50340980

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000068028 (version 78.38)

Entrez gene

11186

UniProt

Q9NS23 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NS23

Antibodypedia

RASSF1 antibodies
 

PROTEIN VIEW

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RASSF1-001
 
RASSF1-002
 
RASSF1-005
 
RASSF1-007
 
RASSF1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RASSF1-001 ENSP00000352323
ENST00000359365
Q9NS23
Show all »
Show » Show » 340 38.8 No 0
RASSF1-002 ENSP00000349547
ENST00000357043
Q9NS23
Show all »
Show » Show » 344 39.2 No 0
RASSF1-005 ENSP00000378558
ENST00000395126
Q9NS23
Show all »
Show » Show » 189 21.9 No 0
RASSF1-007 ENSP00000333327
ENST00000327761
Q9NS23
Show all »
Show » Show » 270 31.2 No 0
RASSF1-201 ENSP00000482696
ENST00000616212
Q9NS23
Show all »
Show » Show » 189 21.9 No 0