OTUD5

GENE INFORMATION

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Gene name

OTUD5 (HGNC Symbol)

Synonyms

DKFZp761A052, DUBA

Description

OTU deubiquitinase 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48922028 - 48958386

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000068308 (version 78.38)

Entrez gene

55593

UniProt

Q96G74 (UniProt - Evidence at protein level)

neXtProt

NX_Q96G74

Antibodypedia

OTUD5 antibodies
 

PROTEIN VIEW

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OTUD5-002
 
OTUD5-003
 
OTUD5-004
 
OTUD5-006
 
OTUD5-201
 
OTUD5-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OTUD5-002 ENSP00000390767
ENST00000455452
H7BZQ3
Show all »
Show » 444 48.9 No 0
OTUD5-003 ENSP00000156084
ENST00000156084
Q96G74
Show all »
Show » Show » 571 60.6 No 0
OTUD5-004 ENSP00000365671
ENST00000376488
Q96G74
Show all »
Show » Show » 566 60.2 No 0
OTUD5-006 ENSP00000401629
ENST00000428668
Q96G74
Show all »
Show » Show » 349 39.2 No 0
OTUD5-201 ENSP00000379969
ENST00000396743
Q96G74
Show all »
Show » Show » 566 60.2 No 0
OTUD5-202 ENSP00000481335
ENST00000610466
Show » 542 58 No 0