SMG6

GENE INFORMATION

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Gene name

SMG6 (HGNC Symbol)

Synonyms

C17orf31, EST1A, KIAA0732, SMG-6

Description

SMG6 nonsense mediated mRNA decay factor (HGNC Symbol)

Entrez gene summary

This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

Chromosome

17

Cytoband

p13.3

Chromosome location (bp)

2059839 - 2303771

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070366 (version 78.38)

Entrez gene

23293

UniProt

Q86US8 (UniProt - Evidence at protein level)

neXtProt

NX_Q86US8

Antibodypedia

SMG6 antibodies
 

PROTEIN VIEW

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SMG6-001
 
SMG6-002
 
SMG6-005
 
SMG6-008
 
SMG6-009
 
SMG6-010
 
SMG6-013
 
SMG6-014
 
SMG6-015
 
SMG6-018
 
SMG6-019
 
SMG6-021
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMG6-001 ENSP00000263073
ENST00000263073
Q86US8
Show all »
Show » Show » 1419 160.5 No 0
SMG6-002 ENSP00000346977
ENST00000354901
Q86US8
Show all »
Show » Show » 511 57.5 No 0
SMG6-005 ENSP00000440283
ENST00000536871
Q86US8
Show all »
Show » Show » 511 57.5 No 0
SMG6-008 ENSP00000465793
ENST00000572369
K7EKV2
Show all »
Show » 139 15.6 No 0
SMG6-009 ENSP00000466139
ENST00000575176
K7ELM2
Show all »
Show » 124 14 No 0
SMG6-010 ENSP00000460273
ENST00000575454
I3L390
Show all »
Show » 208 23.3 Yes 0
SMG6-013 ENSP00000460301
ENST00000570668
I3L3A9
Show all »
Show » 119 13.3 No 0
SMG6-014 ENSP00000458635
ENST00000575663
I3L176
Show all »
Show » 162 18.1 No 0
SMG6-015 ENSP00000459164
ENST00000571442
I3L1W8
Show all »
Show » 164 18.3 No 0
SMG6-018 ENSP00000466951
ENST00000572205
K7ENH7
Show all »
Show » 115 13 No 0
SMG6-019 ENSP00000460898
ENST00000570659
I3L421
Show all »
Show » 163 18.2 No 0
SMG6-021 ENSP00000460191
ENST00000570606
I3L355
Show all »
Show » 123 13.8 No 0