PABPC1 - Gene info - The Human Protein Atlas

PABPC1

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PABPC1 (HGNC Symbol)
Synonyms	PAB1, PABP1, PABPC2, PABPL1
Description	Poly(A) binding protein, cytoplasmic 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	100685816 - 100722809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070756 (version 78.38)
Entrez gene	26986
UniProt	P11940 (UniProt - Evidence at protein level)
neXtProt	NX_P11940
Antibodypedia	PABPC1 antibodies

PROTEIN VIEW

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PABPC1-001		PABPC1-002		PABPC1-003		PABPC1-005		PABPC1-006		PABPC1-007		PABPC1-008		PABPC1-009		PABPC1-012		PABPC1-015		PABPC1-016		PABPC1-017		PABPC1-018		PABPC1-019		PABPC1-020		PABPC1-021		PABPC1-025		PABPC1-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PABPC1-001	ENSP00000313007 ENST00000318607	P11940 Show all » « Hide P11940 [Direct mapping] Polyadenylate-binding protein 1 A0A024R9C1 [Target identity:100%; Query identity:100%] Poly(A) binding protein, cytoplasmic 1, isoform CRA_b {ECO:0000313\|EMBL:EAW91817.1} E7EQV3 [Target identity:92%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429594} H0YB75 [Target identity:28%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428840} E5RJB9 [Target identity:20%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429119} E5RH24 [Target identity:18%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430012} E5RGH3 [Target identity:16%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430159} E5RHG7 [Target identity:11%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429790} E5RFD8 [Target identity:9%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428937} E5RGC4 [Target identity:6%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:5%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0006378 [mRNA polyadenylation] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0008022 [protein C-terminus binding] GO:0008143 [poly(A) binding] GO:0008266 [poly(U) RNA binding] GO:0008494 [translation activator activity] GO:0010467 [gene expression] GO:0010494 [cytoplasmic stress granule] GO:0016020 [membrane] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0030529 [ribonucleoprotein complex] GO:0031047 [gene silencing by RNA] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] GO:0048255 [mRNA stabilization] GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0070062 [extracellular vesicular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000623 [negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]	636	70.7	No	0
PABPC1-002	ENSP00000429594 ENST00000519004	E7EQV3 Show all » « Hide E7EQV3 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429594} H0YB75 [Target identity:30%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428840} E5RGH3 [Target identity:18%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430159}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding]	591	65.7	No	0
PABPC1-003	ENSP00000429395 ENST00000522387	E7ERJ7 Show all » « Hide E7ERJ7 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429395} H0YB75 [Target identity:30%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428840} E5RHG7 [Target identity:12%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429790} E5RFD8 [Target identity:10%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428937} E5RGC4 [Target identity:7%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:6%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding]	604	67.1	No	0
PABPC1-005	ENSP00000428840 ENST00000522658	H0YB75 Show all » « Hide H0YB75 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428840}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	183	19.5	No	0
PABPC1-006	ENSP00000428021 ENST00000520868		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	169	17.8	No	0
PABPC1-007	ENSP00000428190 ENST00000517403		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		187	20.7	No	0
PABPC1-008	ENSP00000430012 ENST00000520142	E5RH24 Show all » « Hide E5RH24 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430012} E5RHG7 [Target identity:63%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429790} E5RFD8 [Target identity:51%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428937} E5RGC4 [Target identity:36%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:32%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	118	13.3	No	0
PABPC1-009	ENSP00000429892 ENST00000523555		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding]	175	19.7	No	0
PABPC1-012	ENSP00000427914 ENST00000519100		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding]	284	32.1	No	0
PABPC1-015	ENSP00000429119 ENST00000521865	E5RJB9 Show all » « Hide E5RJB9 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429119} E5RH24 [Target identity:91%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430012} E5RHG7 [Target identity:58%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429790} E5RFD8 [Target identity:47%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428937} E5RGC4 [Target identity:33%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:29%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	129	14.5	No	0
PABPC1-016	ENSP00000428937 ENST00000521067	E5RFD8 Show all » « Hide E5RFD8 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428937} E5RGC4 [Target identity:70%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:62%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	61	6.9	No	0
PABPC1-017	ENSP00000429790 ENST00000522720	E5RHG7 Show all » « Hide E5RHG7 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429790} E5RFD8 [Target identity:81%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428937} E5RGC4 [Target identity:57%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:50%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	75	8.4	No	0
PABPC1-018	ENSP00000428749 ENST00000520804	E5RGC4 Show all » « Hide E5RGC4 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428749} E5RJM8 [Target identity:88%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	43	4.7	No	0
PABPC1-019	ENSP00000429032 ENST00000519363	E5RJM8 Show all » « Hide E5RJM8 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000429032}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	38	4.1	No	0
PABPC1-020	ENSP00000430159 ENST00000518196	E5RGH3 Show all » « Hide E5RGH3 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430159}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding]	108	12.2	No	0
PABPC1-021	ENSP00000430716 ENST00000518293		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	42	4.3	No	0
PABPC1-025	ENSP00000428030 ENST00000517990	H0YAS7 Show all » « Hide H0YAS7 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000428030}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	136	14.4	No	0
PABPC1-201	ENSP00000478108 ENST00000610907	E5RGH3 Show all » « Hide E5RGH3 [Target identity:20%; Query identity:100%] Polyadenylate-binding protein 1 {ECO:0000313\|Ensembl:ENSP00000430159}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding]	522	58.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.