PVR

GENE INFORMATION

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Gene name

PVR (HGNC Symbol)

Synonyms

CD155, HVED, Necl-5, NECL5, PVS, Tage4

Description

Poliovirus receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

19

Cytoband

q13.31

Chromosome location (bp)

44643798 - 44663583

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073008 (version 78.38)

Entrez gene

5817

UniProt

P15151 (UniProt - Evidence at protein level)

neXtProt

NX_P15151

Antibodypedia

PVR antibodies
 

PROTEIN VIEW

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PVR-001
 
PVR-003
 
PVR-004
 
PVR-005
 
PVR-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PVR-001 ENSP00000402060
ENST00000425690
P15151
Show all »
Show » Show » 417 45.3 Yes 1
PVR-003 ENSP00000383907
ENST00000406449
Show » Show » 392 42.9 Yes 1
PVR-004 ENSP00000385344
ENST00000403059
P15151
Show all »
Show » Show » 372 40.1 Yes 0
PVR-005 ENSP00000466447
ENST00000587785
Show » Show » 70 7.9 No 0
PVR-006 ENSP00000340870
ENST00000344956
P15151
Show all »
Show » Show » 364 39.3 Yes 0