MCM2

GENE INFORMATION

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Gene name

MCM2 (HGNC Symbol)

Synonyms

BM28, CCNL1, cdc19, CDCL1, D3S3194, KIAA0030

Description

Minichromosome maintenance complex component 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

Chromosome

3

Cytoband

q21.3

Chromosome location (bp)

127598223 - 127622436

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073111 (version 78.38)

Entrez gene

4171

UniProt

P49736 (UniProt - Evidence at protein level)

neXtProt

NX_P49736

Antibodypedia

MCM2 antibodies
 

PROTEIN VIEW

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MCM2-001
 
MCM2-005
 
MCM2-007
 
MCM2-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCM2-001 ENSP00000265056
ENST00000265056
P49736
Show all »
Show » Show » 904 101.9 No 0
MCM2-005 ENSP00000420528
ENST00000491422
Q9BWF4
Show all »
Show » Show » 836 94 No 0
MCM2-007 ENSP00000419802
ENST00000480910
C9JZ21
Show all »
Show » Show » 128 14.2 No 0
MCM2-008 ENSP00000418930
ENST00000472731
C9J013
Show all »
Show » Show » 103 11.2 No 0