SRI - Gene info - The Human Protein Atlas

Gene name

SRI

Synonyms

Description

Sorcin (HGNC Symbol)

Entrez gene summary

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

Chromosome

Cytoband

q21.12

Chromosome location (bp)

88205118 - 88226993

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000075142 (version 78.38)

Entrez gene

6717

UniProt

P30626 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SRI-001

ENSP00000265729
ENST00000265729

P30626
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P30626 [Direct mapping]
Sorcin
Q75MZ6 [Target identity:34%; Query identity:100%]
Calcium binding protein amplified in mutlidrug-resistant cells {ECO:0000313|EMBL:AAB96327.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001508 [action potential]
GO:0002020 [protease binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006880 [intracellular sequestering of iron ion]
GO:0006942 [regulation of striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0008016 [regulation of heart contraction]
GO:0010459 [negative regulation of heart rate]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031982 [vesicle]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0042584 [chromaffin granule membrane]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043679 [axon terminus]
GO:0044325 [ion channel binding]
GO:0044326 [dendritic spine neck]
GO:0046982 [protein heterodimerization activity]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051924 [regulation of calcium ion transport]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070062 [extracellular vesicular exosome]
GO:0070491 [repressing transcription factor binding]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901077 [regulation of relaxation of muscle]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]

198

21.7

SRI-003

ENSP00000391148
ENST00000431660

P30626
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P30626 [Direct mapping]
Sorcin

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001508 [action potential]
GO:0002020 [protease binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006880 [intracellular sequestering of iron ion]
GO:0006942 [regulation of striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0008016 [regulation of heart contraction]
GO:0010459 [negative regulation of heart rate]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0042584 [chromaffin granule membrane]
GO:0044325 [ion channel binding]
GO:0046982 [protein heterodimerization activity]
GO:0051924 [regulation of calcium ion transport]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070062 [extracellular vesicular exosome]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901077 [regulation of relaxation of muscle]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]

180

SRI-004

ENSP00000418512
ENST00000490437

C9J0K6
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C9J0K6 [Target identity:100%; Query identity:100%]
Sorcin {ECO:0000313|Ensembl:ENSP00000418512}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005509 [calcium ion binding]

155

17.6

SRI-005

ENSP00000397609
ENST00000419179

B4DHQ6
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B4DHQ6 [Target identity:100%; Query identity:100%]
Sorcin {ECO:0000313|Ensembl:ENSP00000397609}; cDNA FLJ54267, moderately similar to Sorcin {ECO:0000313|EMBL:BAG58218.1}
Q75MZ6 [Target identity:43%; Query identity:100%]
Calcium binding protein amplified in mutlidrug-resistant cells {ECO:0000313|EMBL:AAB96327.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005509 [calcium ion binding]

158

17.1

SRI-012

ENSP00000378137
ENST00000394641

P30626
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P30626 [Direct mapping]
Sorcin

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001508 [action potential]
GO:0002020 [protease binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006880 [intracellular sequestering of iron ion]
GO:0006942 [regulation of striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0008016 [regulation of heart contraction]
GO:0010459 [negative regulation of heart rate]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0042584 [chromaffin granule membrane]
GO:0044325 [ion channel binding]
GO:0046982 [protein heterodimerization activity]
GO:0051924 [regulation of calcium ion transport]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070062 [extracellular vesicular exosome]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901077 [regulation of relaxation of muscle]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]

183

20.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.