ACTL6B

GENE INFORMATION

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Gene name

ACTL6B (HGNC Symbol)

Synonyms

ACTL6, BAF53B

Description

Actin-like 6B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

100643097 - 100656461

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077080 (version 78.38)

Entrez gene

51412

UniProt

O94805 (UniProt - Evidence at protein level)

neXtProt

NX_O94805

Antibodypedia

ACTL6B antibodies
 

PROTEIN VIEW

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ACTL6B-001
 
ACTL6B-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTL6B-001 ENSP00000160382
ENST00000160382
O94805
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Show » Show » 426 46.9 No 0
ACTL6B-002 ENSP00000420151
ENST00000461605
C9JQT4
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Show » 66 7.9 No 0