C12orf5

GENE INFORMATION

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Gene name

C12orf5 (HGNC Symbol)

Synonyms

TIGAR

Description

Chromosome 12 open reading frame 5 (HGNC Symbol)

Entrez gene summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.32

Chromosome location (bp)

4321205 - 4354593

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078237 (version 78.38)

Entrez gene

57103

UniProt

Q9NQ88 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NQ88

Antibodypedia

C12orf5 antibodies
 

PROTEIN VIEW

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C12orf5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C12orf5-001 ENSP00000179259
ENST00000179259
Q9NQ88
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