CEACAM1

GENE INFORMATION

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Gene name

CEACAM1 (HGNC Symbol)

Synonyms

BGP, BGP1, CD66a

Description

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

42507304 - 42561234

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000079385 (version 78.38)

Entrez gene

634

UniProt

P13688 (UniProt - Evidence at protein level)

neXtProt

NX_P13688

Antibodypedia

CEACAM1 antibodies
 

PROTEIN VIEW

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CEACAM1-001
 
CEACAM1-002
 
CEACAM1-006
 
CEACAM1-007
 
CEACAM1-011
 
CEACAM1-012
 
CEACAM1-013
 
CEACAM1-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CEACAM1-001 ENSP00000161559
ENST00000161559
P13688
Show all »
Show » Show » 526 57.6 Yes 1
CEACAM1-002 ENSP00000384709
ENST00000403444
P13688
Show all »
Show » Show » 464 50.5 Yes 1
CEACAM1-006 ENSP00000384083
ENST00000403461
P13688
Show all »
Show » Show » 368 39.9 Yes 1
CEACAM1-007 ENSP00000472633
ENST00000471298
M0R2K4
Show all »
Show » 94 10.4 No 0
CEACAM1-011 ENSP00000244291
ENST00000352591
P13688
Show all »
Show » Show » 430 46.9 Yes 1
CEACAM1-012 ENSP00000351165
ENST00000358394
P13688
Show all »
Show » Show » 461 50.3 Yes 1
CEACAM1-013 ENSP00000471918
ENST00000599389
P13688
Show all »
Show » Show » 399 43.1 Yes 1
CEACAM1-014 ENSP00000471566
ENST00000600172
M0R109
Show all »
Show » 99 11 No 0